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3 records shown · first 60Saudi Community-Based Screening Study on Genetic Variants in β-Cell Dysfunction and Its Role in Women with Gestational Diabetes Mellitus.
PMID 37107681 | PMCID PMC10137495 | DOI 10.3390/genes14040924 · Genes · 2023 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs2237892 | “The purpose of this study was to investigate the genes associated with β-cell dysfunction and their genetic roles in the rs7903146, rs2237892, and rs5219 variants in Saudi women diagnosed with type 2 diabetes mellitus and GDM.” | 0.90 | hgvs_regex_v1 |
| gene | TCF7L2 | “TCF7L2, KCNQ1, and KCNJ11 genes are connected to the mechanism of β-cell dysfunction.” | 0.98 | hgnc_dict_v1 |
| gene | KCNQ1 | “TCF7L2, KCNQ1, and KCNJ11 genes are connected to the mechanism of β-cell dysfunction.” | 0.98 | hgnc_dict_v1 |
| gene | KCNJ11 | “TCF7L2, KCNQ1, and KCNJ11 genes are connected to the mechanism of β-cell dysfunction.” | 0.98 | hgnc_dict_v1 |
Type 2 diabetes associated variants of KCNQ1 strongly confer the risk of cardiovascular disease among the Saudi Arabian population.
PMID 28863213 | PMCID PMC5596376 | DOI 10.1590/1678-4685-GMB-2017-0005 · Genetics and molecular biology · 2017 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs2237892 | “The current study was undertaken to evaluate the association of 3 polymorphisms of KCNQ1 (rs2237892, rs151290 and rs2237895) with T2D and/or CVD.” | 0.90 | hgvs_regex_v1 |
| gene | KCNQ1 | “Type 2 diabetes associated variants of KCNQ1 strongly confer the risk of cardiovascular disease among the Saudi Arabian population.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Type 2 diabetes associated variants of KCNQ1 strongly confer the risk of cardiovascular disease among the Saudi Arabian population.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Type 2 diabetes associated variants of KCNQ1 strongly confer the risk of cardiovascular disease among the Saudi Arabian population. Patients diagnosed with either T2D (320 patients), CVD (250 patients) or both (60 patients) and 516 healthy controls were genotyped by TaqMan assay run on a real time PCR thermocycler.” | 0.95 | saudi_context_rules_v1 |
Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population.
PMID 25501231 | DOI 10.4238/2014.December.4.14 · Genetics and molecular research : GMR · 2014 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs2237892 | “In the present study, we examined the association between variants in fat mass- and obesity-associated [rs9939609 (A/T)], melanocortin 4 receptor [rs17782313 (C/T), and rs12970134 (A/G)], SLC30A8 [rs13266634 (C/T)], and a member of the potassium voltage-gated channels [rs2237892(C/T)] genes in diabetes patients from Saudi Arabia.” | 0.90 | hgvs_regex_v1 |
| gene | FTO | “Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population.” | 0.98 | hgnc_dict_v1 |
| gene | MC4R | “Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population.” | 0.98 | hgnc_dict_v1 |
| gene | SLC30A8 | “Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population.” | 0.98 | hgnc_dict_v1 |