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1 records shown · first 60Low levels of soluble DPP4 among Saudis may have constituted a risk factor for MERS endemicity.
PMID 35413090 | PMCID PMC9004781 | DOI 10.1371/journal.pone.0266603 · PloS one · 2022 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs35128070 | “The plasma level of sDPP4 was measured by ELISA and the following SNPs in the DPP4 gene; rs35128070, rs1861978, rs79700168, and rs17574, were genotyped by TaqMan SNP genotyping assay.” | 0.90 | hgvs_regex_v1 |
| gene | DPP4 | “Low levels of soluble DPP4 among Saudis may have constituted a risk factor for MERS endemicity.” | 0.98 | hgnc_dict_v1 |
| phenotype | MERS | “Low levels of soluble DPP4 among Saudis may have constituted a risk factor for MERS endemicity.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Most of the cases of Middle East respiratory syndrome coronavirus (MERS-CoV) were reported in Saudi Arabia. We investigated whether the Saudi population has lower levels of sDPP4 which makes them more susceptible to MERS-CoV infection and, therefore, could explain the larger number of cases from the country. Blood samples were collected from 219 Saudi blood donors and 200 blood donors from other ethnic groups. Herein, we report that the Saudi population has lower levels of plasma sDPP4 than other ethnic groups, which is associated with genetic variants in the DPP4 gene. This may have contributed to increase the susceptibility of the Saudi population to MERS-CoV infection and could be a factor in the long-lasting persistence of the virus in the country.” | 0.95 | saudi_context_rules_v1 |