Advanced search
Combine gene, variant, phenotype, region and year filters
Every result shows the extracted entities next to the sentences that support them; rows for the searched entities come first.
Transparent by designEvery result links extracted entities to its source sentence and publication identifier.
Knowledge-base search
Publications
5 records shown · first 60Pharmacogenetic insights into ABCB1, ABCC2, CYP1A2, and CYP2B6 variants with epilepsy susceptibility among Egyptian Children: A retrospective case-control study.
PMID 39265352 | DOI 10.1016/j.intimp.2024.113073 · International immunopharmacology · 2024 · 10 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs3745274 | “Genotyping of the rs2032582, rs717620, rs2273697, rs762551, and rs3745274 variants was performed using the PCR technique.” | 0.90 | hgvs_regex_v1 |
| gene | ABCB1 | “Pharmacogenetic insights into ABCB1, ABCC2, CYP1A2, and CYP2B6 variants with epilepsy susceptibility among Egyptian Children: A retrospective case-control study.” | 0.98 | hgnc_dict_v1 |
| gene | ABCC2 | “Pharmacogenetic insights into ABCB1, ABCC2, CYP1A2, and CYP2B6 variants with epilepsy susceptibility among Egyptian Children: A retrospective case-control study.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A2 | “Pharmacogenetic insights into ABCB1, ABCC2, CYP1A2, and CYP2B6 variants with epilepsy susceptibility among Egyptian Children: A retrospective case-control study.” | 0.98 | hgnc_dict_v1 |
Pharmacogenetic predictors of nevirapine pharmacokinetics in Ghanaian children living with HIV with or without TB coinfection.
PMID 33839311 | PMCID PMC8636019 | DOI 10.1016/j.meegid.2021.104856 · Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs3745274 | “Using step-wise regression, CYP2B6 rs3745274 and NR1I2 rs6785049 SNPs were independent as well as joint predictors of NVP AUC0-12h, Cmin, and CL/F.” | 0.90 | hgvs_regex_v1 |
| gene | CYP2B6 | “Genotyping for CYP2B6, CYP2A6, CYP3A5, ABCB1, NR1I2, and NR1I3 single nucleotide polymorphism (SNPs) was performed by TaqMan® allelic discrimination method.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2A6 | “Genotyping for CYP2B6, CYP2A6, CYP3A5, ABCB1, NR1I2, and NR1I3 single nucleotide polymorphism (SNPs) was performed by TaqMan® allelic discrimination method.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A5 | “Genotyping for CYP2B6, CYP2A6, CYP3A5, ABCB1, NR1I2, and NR1I3 single nucleotide polymorphism (SNPs) was performed by TaqMan® allelic discrimination method.” | 0.98 | hgnc_dict_v1 |
Human cytochrome P450 2B6 genetic variability in Botswana: a case of haplotype diversity and convergent phenotypes.
PMID 29559695 | PMCID PMC5861095 | DOI 10.1038/s41598-018-23350-1 · Scientific reports · 2018 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs3745274 | “A total of 570 subjects were analyzed for CYP2B6 polymorphisms at position 516 G > T (rs3745274), 785 A > G (rs2279343) and 983 T > C (rs28399499).” | 0.90 | hgvs_regex_v1 |
| gene | CYP2B6 | “Identification of inter-individual variability for drug metabolism through cytochrome P450 2B6 (CYP2B6) enzyme is important for understanding the differences in clinical responses to malaria and HIV.” | 0.98 | hgnc_dict_v1 |
| phenotype | malaria | “Identification of inter-individual variability for drug metabolism through cytochrome P450 2B6 (CYP2B6) enzyme is important for understanding the differences in clinical responses to malaria and HIV.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs2279343 | “A total of 570 subjects were analyzed for CYP2B6 polymorphisms at position 516 G > T (rs3745274), 785 A > G (rs2279343) and 983 T > C (rs28399499).” | 0.90 | hgvs_regex_v1 |
Distribution of CYP2B6 516G/T pharmacogenetically important polymorphism in the Ukrainian population.
PMID 29991909 | PMCID PMC6035515 | DOI 10.1016/j.jsps.2018.02.027 · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs3745274 | “Genotyping of the CYP2B6 (rs3745274) polymorphism in the study subjects was carried out using a polymerase chain reaction.” | 0.90 | hgvs_regex_v1 |
| gene | CYP2B6 | “Distribution of CYP2B6 516G/T pharmacogenetically important polymorphism in the Ukrainian population.” | 0.98 | hgnc_dict_v1 |
Gene-gene interactions between DRD3, MRP4 and CYP2B6 polymorphisms and its influence on the pharmacokinetic parameters of efavirenz in HIV infected patients.
PMID 27665700 | DOI 10.1016/j.dmpk.2016.06.001 · Drug metabolism and pharmacokinetics · 2016 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs3745274 | “The most relevant associations for metabolizing enzymes were found in CYP2B6 (rs3745274), in agreement with previous studies.” | 0.90 | hgvs_regex_v1 |
| gene | DRD3 | “Gene-gene interactions between DRD3, MRP4 and CYP2B6 polymorphisms and its influence on the pharmacokinetic parameters of efavirenz in HIV infected patients.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2B6 | “Gene-gene interactions between DRD3, MRP4 and CYP2B6 polymorphisms and its influence on the pharmacokinetic parameters of efavirenz in HIV infected patients.” | 0.98 | hgnc_dict_v1 |
| variant | rs1751034 | “The influence of transporters on the kinetics of EFV was also proved with significant correlations between the PK parameters of EFV and MRP4 (rs1751034, rs2274407).” | 0.90 | hgvs_regex_v1 |