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3 records shown · first 60Association of the polymorphism of the Toll-like receptor (TLR)-3 and TLR-9 genes with hepatitis C virus-specific cell-mediated immunity outcomes among Egyptian health-care workers.
PMID 32939755 | PMCID PMC7744502 | DOI 10.1111/cei.13514 · Clinical and experimental immunology · 2021 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs3775290 | “We previously reported that the TLR-3.rs3775290 CC genotype was associated with HCV chronicity and that the TLR-9 gene played no major role in this infection.” | 0.90 | hgvs_regex_v1 |
| phenotype | hepatitis C | “Association of the polymorphism of the Toll-like receptor (TLR)-3 and TLR-9 genes with hepatitis C virus-specific cell-mediated immunity outcomes among Egyptian health-care workers.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs5743836 | “This study identified the role of TLR-3.rs3775290 (c.1377C/T), TLR-9.rs5743836 (-1237T→C) and TLR-9.rs352140 (G2848A) gene polymorphisms in predicting the outcome of HCV-specific cell-mediated immunity (CMI) among Egyptian health-care workers (HCWs).” | 0.90 | hgvs_regex_v1 |
| variant | rs352140 | “This study identified the role of TLR-3.rs3775290 (c.1377C/T), TLR-9.rs5743836 (-1237T→C) and TLR-9.rs352140 (G2848A) gene polymorphisms in predicting the outcome of HCV-specific cell-mediated immunity (CMI) among Egyptian health-care workers (HCWs).” | 0.90 | hgvs_regex_v1 |
The association of single nucleotide polymorphisms of Toll-like receptor 3, Toll-like receptor 7 and Toll-like receptor 8 genes with the susceptibility to HCV infection.
PMID 29947302 | DOI 10.1080/09674845.2018.1492186 · British journal of biomedical science · 2018 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs3775290 | “RESULTS: Carriage of the C allele in three SNPs of TLR3 (rs3775290, rs3775291, and rs5743312), the C allele in TLR7 (rs3853839) in females only, and the C allele in TLR8 (rs3764879) in males only were significantly higher in SVC group than CHC group (P < 0.001), while carriage of the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both males and females were significantly higher in CHC infection more than SVC group (P < 0.001).” | 0.90 | hgvs_regex_v1 |
| gene | TLR3 | “We hypothesized that one or more variant(s) of TLR3, TLR7 and TLR8 are associated with different outcomes of HCV infection.” | 0.98 | hgnc_dict_v1 |
| gene | TLR7 | “We hypothesized that one or more variant(s) of TLR3, TLR7 and TLR8 are associated with different outcomes of HCV infection.” | 0.98 | hgnc_dict_v1 |
| gene | TLR8 | “We hypothesized that one or more variant(s) of TLR3, TLR7 and TLR8 are associated with different outcomes of HCV infection.” | 0.98 | hgnc_dict_v1 |
Association of Toll-like receptor 3 and Toll-like receptor 9 single-nucleotide polymorphisms with hepatitis C virus persistence among Egyptians.
PMID 29860675 | DOI 10.1007/s00705-018-3893-8 · Archives of virology · 2018 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs3775290 | “This study examined whether there is a potential association between single-nucleotide polymorphisms (SNPs) in the TLR3.rs3775290 (c.1377C/T), TLR9.rs5743836 (-1237T→C) and TLR9.rs352140 (G2848A) genes and HCV infection among Egyptian patients and healthcare workers (HCWs).” | 0.90 | hgvs_regex_v1 |
| gene | TLR3 | “TLR3 detects dsRNA of viruses while TLR9 recognizes bacterial and viral unmethylated CpG motifs.” | 0.98 | hgnc_dict_v1 |
| gene | TLR9 | “TLR3 detects dsRNA of viruses while TLR9 recognizes bacterial and viral unmethylated CpG motifs.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatitis C | “Association of Toll-like receptor 3 and Toll-like receptor 9 single-nucleotide polymorphisms with hepatitis C virus persistence among Egyptians.” | 0.98 | phenotype_alias_lexicon_v2 |