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7 records shown · first 60Study of gene polymorphisms in Toll-like receptor 2 in patients with acute lymphoblastic leukemia.
PMID 39040297 | PMCID PMC11261853 | DOI 10.1016/j.heliyon.2024.e33754 · Heliyon · 2024 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs3804100 | “In total, Five SNPs were statistically evaluated in the TLR2 (rs1898830 A/G, rs3804099 T/C, rs3804100 T/C, rs1339 T/C, and rs1337 C/G), which may influence the susceptibility of ALL.” | 0.90 | hgvs_regex_v1 |
| gene | TLR2 | “Toll-like receptor 2 (TLR2) play an essential role in innate immunity.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “Study of gene polymorphisms in Toll-like receptor 2 in patients with acute lymphoblastic leukemia.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Study of gene polymorphisms in Toll-like receptor 2 in patients with acute lymphoblastic leukemia. CONCLUSIONS: This study shows that TLR2 could be an independent prognostic factor of ALL risks in the Saudi population.” | 0.95 | saudi_context_rules_v1 |
Common variants in toll-like receptor family genes and risk of gastric cancer: a systematic review and meta-analysis.
PMID 38090147 | PMCID PMC10715274 | DOI 10.3389/fgene.2023.1280051 · Frontiers in genetics · 2023 · 15 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs3804100 | “No significant association was detected for TLR-2-196 to -174de (Delta22), TLR-2 rs3804100, TLR-4 rs11536889, TLR-4 rs11536878, TLR-4 rs2770150, TLR-4 rs10116253, TLR-4 rs1927911, TLR-4 rs10983755, TLR-4 rs10759932, TLR-4 rs1927914, and TLR-10 rs10004195.” | 0.90 | hgvs_regex_v1 |
| phenotype | gastric cancer | “Common variants in toll-like receptor family genes and risk of gastric cancer: a systematic review and meta-analysis.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs4986790 | “Variations in TLR-4 rs4986790, TLR-4 rs4986791, TLR-5 rs5744174, and TLR-9 rs187084 were significantly associated with increased risk of GC in different genetic models.” | 0.90 | hgvs_regex_v1 |
| variant | rs4986791 | “Variations in TLR-4 rs4986790, TLR-4 rs4986791, TLR-5 rs5744174, and TLR-9 rs187084 were significantly associated with increased risk of GC in different genetic models.” | 0.90 | hgvs_regex_v1 |
Synonymous and non-synonymous polymorphisms in toll-like receptor 2 (TLR2) gene among complicated measles cases at a tertiary care hospital, Peshawar, Pakistan.
PMID 34732556 | PMCID PMC9149733 | DOI 10.15537/smj.2021.42.11.20210515 · Saudi medical journal · 2021 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs3804100 | “Among these, rs1816702 was marked to 5 untranslated region section of TLR2 gene, while rs3804099 and rs3804100 were identified in the coding region.” | 0.90 | hgvs_regex_v1 |
| gene | TLR2 | “Synonymous and non-synonymous polymorphisms in toll-like receptor 2 (TLR2) gene among complicated measles cases at a tertiary care hospital, Peshawar, Pakistan.” | 0.98 | hgnc_dict_v1 |
| variant | rs1816702 | “Among these, rs1816702 was marked to 5 untranslated region section of TLR2 gene, while rs3804099 and rs3804100 were identified in the coding region.” | 0.90 | hgvs_regex_v1 |
| variant | rs3804099 | “Among these, rs1816702 was marked to 5 untranslated region section of TLR2 gene, while rs3804099 and rs3804100 were identified in the coding region.” | 0.90 | hgvs_regex_v1 |
Association of toll-like receptors 2, 4, 9 and 10 genes polymorphisms and Helicobacter pylori-related gastric diseases in Saudi patients.
PMID 32719215 | DOI 10.4103/ijmm.IJMM_20_164 · Indian journal of medical microbiology · 2020 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs3804100 | “TLR2 SNPs (rs3804099 and rs3804100) showed no significant statistical difference between H. pylori-infected patients and the controls.” | 0.90 | hgvs_regex_v1 |
| gene | TLR2 | “MATERIALS AND METHODS: The association between the common single nucleotide polymorphisms (SNPs) in the genes of TLR2, 4, 9 and 10 and H. pylori-related gastric diseases were investigated by molecular methods after the confirmation of H. pylori infection.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “RESULTS: The results showed a significant association between TLR4 SNPs (rs 4986790 and rs 4986791) and the presence of H. pylori infection, especially in chronic gastritis patient group.” | 0.98 | hgnc_dict_v1 |
| phenotype | gastric cancer | “The study included 210 patients in three groups; chronic gastritis (n = 90), peptic ulcer disease (PUD) (n = 75) and gastric carcinoma (n = 45).” | 0.93 | phenotype_alias_lexicon_v2 |
Potential role of Toll-like receptor 2 expression and polymorphisms in colon cancer susceptibility in the Saudi Arabian population.
PMID 30532554 | PMCID PMC6241690 | DOI 10.2147/OTT.S168478 · OncoTargets and therapy · 2018 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs3804100 | “METHODS: Real-time PCR and immunohistochemistry were used to investigate TLR2 gene expression and to evaluate the potential risk of predisposition to colon cancer caused by three tagging single-nucleotide polymorphisms (SNPs) on TLR2, including rs3804100, rs4696480, and rs3804099.” | 0.90 | hgvs_regex_v1 |
| gene | TLR2 | “Our aim was to investigate the expression and polymorphisms of TLR2 and their association with colon cancer.” | 0.98 | hgnc_dict_v1 |
| phenotype | colorectal cancer | “Potential role of Toll-like receptor 2 expression and polymorphisms in colon cancer susceptibility in the Saudi Arabian population.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Potential role of Toll-like receptor 2 expression and polymorphisms in colon cancer susceptibility in the Saudi Arabian population. TaqMan assay was conducted on samples from 115 patients with colon cancer and 102 age- and sex-matched normal individuals.” | 0.95 | saudi_context_rules_v1 |
No genetic relationship between TLR2 rs4696480, rs3804100, and rs3804099 gene polymorphisms and female breast cancer in Saudi populations.
PMID 28490891 | PMCID PMC5415011 | DOI 10.2147/OTT.S121618 · OncoTargets and therapy · 2017 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs3804100 | “No genetic relationship between TLR2 rs4696480, rs3804100, and rs3804099 gene polymorphisms and female breast cancer in Saudi populations.” | 0.90 | hgvs_regex_v1 |
| gene | TLR2 | “No genetic relationship between TLR2 rs4696480, rs3804100, and rs3804099 gene polymorphisms and female breast cancer in Saudi populations.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “No genetic relationship between TLR2 rs4696480, rs3804100, and rs3804099 gene polymorphisms and female breast cancer in Saudi populations.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “No genetic relationship between TLR2 rs4696480, rs3804100, and rs3804099 gene polymorphisms and female breast cancer in Saudi populations. Breast cancer (BC) is the most common cause of cancer-related deaths among women in the Kingdom of Saudi Arabia. Here, we investigated the potential correlation of three TLR2 single-nucleotide polymorphisms (SNPs; rs3804100, rs4696480, and rs3804099) with the development of BC in female patients from Saudi Arabia. These findings indicate that there is no association between the TLR2 polymorphisms tested and BC susceptibility in the female population from the Kingdom of Saudi Arabia.” | 0.95 | saudi_context_rules_v1 |
Effect of smoking on the genetic makeup of toll-like receptors 2 and 6.
PMID 27920557 | PMCID PMC5123654 | DOI 10.2147/OTT.S109650 · OncoTargets and therapy · 2016 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs3804100 | “The SNPs used were rs3804100 (1350 T/C, Ser450Ser) and rs3804099 (597 T/C, Asn199Asn) for TLR2 and rs3796508 (979 G/A, Val327Met) and rs5743810 (745 T/C, Ser249Pro) for TLR6.” | 0.90 | hgvs_regex_v1 |
| gene | TLR2 | “OBJECTIVE: In this study, the genotype frequencies of TLR2 and TLR6 in smoking and nonsmoking population were examined.” | 0.98 | hgnc_dict_v1 |
| gene | TLR6 | “OBJECTIVE: In this study, the genotype frequencies of TLR2 and TLR6 in smoking and nonsmoking population were examined.” | 0.98 | hgnc_dict_v1 |
| phenotype | lung cancer | “BACKGROUND: Cigarette smoking is a major risk factor for lung cancer, asthma, and oral cancer, and is central to the altered innate immune responsiveness to infection.” | 0.98 | phenotype_alias_lexicon_v2 |