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3 records shown · first 60A CD40 variant is associated with systemic bone loss among patients with rheumatoid arthritis.
PMID 35107652 | DOI 10.1007/s10067-021-05998-9 · Clinical rheumatology · 2022 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs3844283 | “METHODS: IRAK-1 rs3027898, IRAK-2 rs3844283, IRAK-2 rs708035, IFIH1 rs1990760, CD40 rs48104850, TNFAIP3 rs2230926, and miR146-a rs2910164 were genotyped in 176 adult RA patients.” | 0.90 | hgvs_regex_v1 |
| gene | CD40 | “A CD40 variant is associated with systemic bone loss among patients with rheumatoid arthritis.” | 0.98 | hgnc_dict_v1 |
| gene | IFIH1 | “METHODS: IRAK-1 rs3027898, IRAK-2 rs3844283, IRAK-2 rs708035, IFIH1 rs1990760, CD40 rs48104850, TNFAIP3 rs2230926, and miR146-a rs2910164 were genotyped in 176 adult RA patients.” | 0.98 | hgnc_dict_v1 |
| gene | TNFAIP3 | “METHODS: IRAK-1 rs3027898, IRAK-2 rs3844283, IRAK-2 rs708035, IFIH1 rs1990760, CD40 rs48104850, TNFAIP3 rs2230926, and miR146-a rs2910164 were genotyped in 176 adult RA patients.” | 0.98 | hgnc_dict_v1 |
IRAK2 is associated with systemic lupus erythematosus risk.
PMID 31650390 | DOI 10.1007/s10067-019-04781-1 · Clinical rheumatology · 2020 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs3844283 | “OBJECTIVES: The aim of the present study was to test the association between IRAK2 rs708035 and rs3844283 with SLE.” | 0.90 | hgvs_regex_v1 |
| gene | IRAK2 | “IRAK2 is associated with systemic lupus erythematosus risk.” | 0.98 | hgnc_dict_v1 |
| phenotype | systemic lupus erythematosus | “IRAK2 is associated with systemic lupus erythematosus risk.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | rheumatoid arthritis | “IRAKs have been previously incriminated in autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis and inhibition of IRAKs has been recently regarded as a potential therapeutic strategy for SLE.” | 0.98 | phenotype_alias_lexicon_v2 |
IRAK2 is associated with susceptibility to rheumatoid arthritis.
PMID 29129009 | DOI 10.1007/s10067-017-3906-0 · Clinical rheumatology · 2018 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs3844283 | “This study was performed to investigate the association of the single nucleotide polymorphisms of interleukin-1 receptor-associated kinase 2 (IRAK2) rs3844283 and rs708035 with rheumatoid arthritis (RA).” | 0.90 | hgvs_regex_v1 |
| gene | IRAK2 | “IRAK2 is associated with susceptibility to rheumatoid arthritis.” | 0.98 | hgnc_dict_v1 |
| phenotype | rheumatoid arthritis | “IRAK2 is associated with susceptibility to rheumatoid arthritis.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs708035 | “This study was performed to investigate the association of the single nucleotide polymorphisms of interleukin-1 receptor-associated kinase 2 (IRAK2) rs3844283 and rs708035 with rheumatoid arthritis (RA).” | 0.90 | hgvs_regex_v1 |