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12 records shown · first 60Association of TLR4 gene rs4986790 and rs4986791 polymorphisms with asthma susceptibility: meta-analysis and trial sequential analysis.
PMID 38853478 | PMCID PMC11268470 | DOI 10.5144/0256-4947.2024.183 · Annals of Saudi medicine · 2024 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4986790 | “Association of TLR4 gene rs4986790 and rs4986791 polymorphisms with asthma susceptibility: meta-analysis and trial sequential analysis.” | 0.90 | hgvs_regex_v1 |
| gene | TLR4 | “Association of TLR4 gene rs4986790 and rs4986791 polymorphisms with asthma susceptibility: meta-analysis and trial sequential analysis.” | 0.98 | hgnc_dict_v1 |
| phenotype | asthma | “Association of TLR4 gene rs4986790 and rs4986791 polymorphisms with asthma susceptibility: meta-analysis and trial sequential analysis.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs4986791 | “Association of TLR4 gene rs4986790 and rs4986791 polymorphisms with asthma susceptibility: meta-analysis and trial sequential analysis.” | 0.90 | hgvs_regex_v1 |
Common variants in toll-like receptor family genes and risk of gastric cancer: a systematic review and meta-analysis.
PMID 38090147 | PMCID PMC10715274 | DOI 10.3389/fgene.2023.1280051 · Frontiers in genetics · 2023 · 15 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4986790 | “Variations in TLR-4 rs4986790, TLR-4 rs4986791, TLR-5 rs5744174, and TLR-9 rs187084 were significantly associated with increased risk of GC in different genetic models.” | 0.90 | hgvs_regex_v1 |
| phenotype | gastric cancer | “Common variants in toll-like receptor family genes and risk of gastric cancer: a systematic review and meta-analysis.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs4986791 | “Variations in TLR-4 rs4986790, TLR-4 rs4986791, TLR-5 rs5744174, and TLR-9 rs187084 were significantly associated with increased risk of GC in different genetic models.” | 0.90 | hgvs_regex_v1 |
| variant | rs5744174 | “Variations in TLR-4 rs4986790, TLR-4 rs4986791, TLR-5 rs5744174, and TLR-9 rs187084 were significantly associated with increased risk of GC in different genetic models.” | 0.90 | hgvs_regex_v1 |
Molecular Effect of Variants in Toll-like Receptor 4 Gene in Saudi Patients with Type 2 Diabetes Mellitus.
PMID 37830554 | PMCID PMC10571932 | DOI 10.3390/cells12192340 · Cells · 2023 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4986790 | “We investigated the relationship between rs11536889, rs4986790, and rs4986791 SNPs in the TLR4 gene and T2DM in the Saudi population; 105 patients with T2DM and 105 healthy controls were analyzed.” | 0.90 | hgvs_regex_v1 |
| gene | TLR4 | “Single-nucleotide polymorphisms (SNPs) in the Toll-like receptor 4 (TLR4) gene have been documented in type 2 diabetes mellitus (T2DM) and other diseases in the Saudi population.” | 0.98 | hgnc_dict_v1 |
| gene | DBP | “Analysis of variance showed that waist (p = 0.0005) and hip circumferences (p = 0.002) in rs4986790 and rs4986791 SNPs, in SBP (p = 0.001), DBP (p = 0.002), and HDLc levels (p = 0.003), were associated with T2DM subjects.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Molecular Effect of Variants in Toll-like Receptor 4 Gene in Saudi Patients with Type 2 Diabetes Mellitus.” | 0.98 | phenotype_alias_lexicon_v2 |
Association of single-nucleotide polymorphisms in tumour necrosis factor and human leukocyte antigens genes with type 1 diabetes.
PMID 34018329 | DOI 10.1111/iji.12535 · International journal of immunogenetics · 2021 · 17 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4986790 | “Twelve SNPs were investigated as follows: rs16944 (IL-1B), rs1143634 (IL-1B), rs1800587 (IL-1A), rs2069762 (IL-2), rs3212227 (IL-12B), rs2234650 (IL-1R1), rs315952 (IL-1RN), rs3804099 (TLR2), rs4986790 (TLR4), rs4986791 (TLR4), rs1800629 (TNF) and rs361525 (TNF).” | 0.90 | hgvs_regex_v1 |
| gene | HLA-DRB1 | “In this study, we compared frequencies of HLA-DRB1 alleles and single-nucleotide polymorphisms (SNPs) associated the genes coding for: toll-like receptors (TLRs), tumour necrosis factor (TNF), interleukin-1 (IL-1), interleukin-1 receptor type 1 (IL-1R1), interleukin-1 receptor antagonist (IL-1RN), interleukin-2 (IL-2) and interleukin-12B (IL-12B), between T1D patients and healthy controls.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “In this study, we compared frequencies of HLA-DRB1 alleles and single-nucleotide polymorphisms (SNPs) associated the genes coding for: toll-like receptors (TLRs), tumour necrosis factor (TNF), interleukin-1 (IL-1), interleukin-1 receptor type 1 (IL-1R1), interleukin-1 receptor antagonist (IL-1RN), interleukin-2 (IL-2) and interleukin-12B (IL-12B), between T1D patients and healthy controls.” | 0.98 | hgnc_dict_v1 |
| gene | TLR2 | “Twelve SNPs were investigated as follows: rs16944 (IL-1B), rs1143634 (IL-1B), rs1800587 (IL-1A), rs2069762 (IL-2), rs3212227 (IL-12B), rs2234650 (IL-1R1), rs315952 (IL-1RN), rs3804099 (TLR2), rs4986790 (TLR4), rs4986791 (TLR4), rs1800629 (TNF) and rs361525 (TNF).” | 0.98 | hgnc_dict_v1 |
Association of toll-like receptor 4, 5 and 10 polymorphisms with Helicobacter pylori-positive peptic ulcer disease in a center in Jordan.
PMID 34420402 | PMCID PMC8380278 | DOI 10.5144/0256-4947.2021.206 · Annals of Saudi medicine · 2021 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4986790 | “OBJECTIVE: Investigate the susceptibility and severity of H pylori infection with host TLR4 (rs11536889, rs4986790, rs200109652, rs10759932), TLR5 (rs5744174, rs2072493, rs746250566), TLR10 (rs559182335, rs10004195) polymorphisms.” | 0.90 | hgvs_regex_v1 |
| gene | TLR4 | “Polymorphisms in host genes such as the toll-like receptor 4 (TLR4) might affect the susceptibility and severity of infection and treatment success.” | 0.98 | hgnc_dict_v1 |
| gene | TLR5 | “OBJECTIVE: Investigate the susceptibility and severity of H pylori infection with host TLR4 (rs11536889, rs4986790, rs200109652, rs10759932), TLR5 (rs5744174, rs2072493, rs746250566), TLR10 (rs559182335, rs10004195) polymorphisms.” | 0.98 | hgnc_dict_v1 |
| gene | TLR10 | “OBJECTIVE: Investigate the susceptibility and severity of H pylori infection with host TLR4 (rs11536889, rs4986790, rs200109652, rs10759932), TLR5 (rs5744174, rs2072493, rs746250566), TLR10 (rs559182335, rs10004195) polymorphisms.” | 0.98 | hgnc_dict_v1 |
Toll-like receptor 4 polymorphisms in Saudi population with cardiovascular diseases.
PMID 31328431 | PMCID PMC7650605 | DOI 10.1002/mgg3.852 · Molecular genetics & genomic medicine · 2019 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4986790 | “METHODS: Three tag single-nucleotide polymorphisms (rs2770150, rs10759931, and rs4986790) in TLR4 were studied on 222 unrelated patients with cardiovascular diseases and 190 healthy volunteers.” | 0.90 | hgvs_regex_v1 |
| gene | TLR4 | “BACKGROUND: Toll-like receptors play a substantial role in innate immunity and the effects of TLR4 genetic variants on cardiovascular diseases are still largely unknown.” | 0.98 | hgnc_dict_v1 |
| phenotype | hypertension | “Furthermore, the genotype frequency of rs2770150 had a significant association with cardiovascular diseases in patients without hypertension and G allele of rs10759931 significantly increased the risk of cardiovascular diseases in patients that smoked.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Toll-like receptor 4 polymorphisms in Saudi population with cardiovascular diseases. Therefore, we aimed to investigate the effects of TLR4 polymorphisms on cardiovascular diseases risk in the Saudi population. METHODS: Three tag single-nucleotide polymorphisms (rs2770150, rs10759931, and rs4986790) in TLR4 were studied on 222 unrelated patients with cardiovascular diseases and 190 healthy volunteers.” | 0.95 | saudi_context_rules_v1 |
Toll-like receptor 4 as a predictor of clinical outcomes of estrogen receptor-negative breast cancer in Saudi women.
PMID 28280355 | PMCID PMC5338938 | DOI 10.2147/OTT.S112165 · OncoTargets and therapy · 2017 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4986790 | “Four TLR-4 polymorphisms (rs2770150, rs10759931, rs10759932, and rs4986790) were studied using 127 breast cancer patients and 117 controls.” | 0.90 | hgvs_regex_v1 |
| phenotype | breast cancer | “Toll-like receptor 4 as a predictor of clinical outcomes of estrogen receptor-negative breast cancer in Saudi women.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Toll-like receptor 4 as a predictor of clinical outcomes of estrogen receptor-negative breast cancer in Saudi women. The aim of this study was to investigate the association of the common polymorphisms of Toll-like receptor 4 (TLR-4) with breast cancer development in the Saudi Arabian population. Four TLR-4 polymorphisms (rs2770150, rs10759931, rs10759932, and rs4986790) were studied using 127 breast cancer patients and 117 controls.” | 0.95 | saudi_context_rules_v1 |
| variant | rs2770150 | “Four TLR-4 polymorphisms (rs2770150, rs10759931, rs10759932, and rs4986790) were studied using 127 breast cancer patients and 117 controls.” | 0.90 | hgvs_regex_v1 |
Analysis of toll-like receptor rs4986790 polymorphism in Saudi patients with primary open angle glaucoma.
PMID 27064537 | DOI 10.3109/13816810.2016.1151900 · Ophthalmic genetics · 2017 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4986790 | “Analysis of toll-like receptor rs4986790 polymorphism in Saudi patients with primary open angle glaucoma.” | 0.90 | hgvs_regex_v1 |
| gene | TLR4 | “Comparing cases to controls as regards co-morbidity with other systemic diseases, there were no statistically significant differences between groups in all assessed diseases except for a family history of glaucoma (p = 0.014) Conclusions: In conclusion, we could not detect any direct link between genotypes or allele frequencies of SNP rs4986790 in the TLR4 gene and POAG.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia | “Analysis of toll-like receptor rs4986790 polymorphism in Saudi patients with primary open angle glaucoma. BACKGROUND: To investigate whether SNP rs4986790 in toll-like receptors (TLRs) is a risk factor for primary open angle glaucoma (POAG) in a Saudi population. MATERIALS AND METHODS: A cohort of 85 unrelated POAG patients and 95 unrelated control subjects from Saudi Arabia were genotyped utilizing Taq-Man® assay.” | 0.95 | saudi_context_rules_v1 |
Association of single nucleotide polymorphisms in pro-inflammatory cytokine and toll-like receptor genes with pediatric hematogenous osteomyelitis.
PMID 27323068 | DOI 10.4238/gmr.15027718 · Genetics and molecular research : GMR · 2016 · 16 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4986790 | “In this study, we investigated the contribution of SNPs in interleukin (IL)-1B1 (rs16944), IL1A (rs1800587), IL1B (rs1143634), toll-like receptor (TLR)-2 (rs3804099), TLR4 (rs4986790), TLR4 (rs4986791), IL1R (rs2234650), tumor necrosis factor (TNF)-α (rs1800629), TNF (rs361525), and IL1RN (rs315952) towards the development of HO in Saudi patients and compared to healthy controls.” | 0.90 | hgvs_regex_v1 |
| gene | IL1A | “In this study, we investigated the contribution of SNPs in interleukin (IL)-1B1 (rs16944), IL1A (rs1800587), IL1B (rs1143634), toll-like receptor (TLR)-2 (rs3804099), TLR4 (rs4986790), TLR4 (rs4986791), IL1R (rs2234650), tumor necrosis factor (TNF)-α (rs1800629), TNF (rs361525), and IL1RN (rs315952) towards the development of HO in Saudi patients and compared to healthy controls.” | 0.98 | hgnc_dict_v1 |
| gene | IL1B | “In this study, we investigated the contribution of SNPs in interleukin (IL)-1B1 (rs16944), IL1A (rs1800587), IL1B (rs1143634), toll-like receptor (TLR)-2 (rs3804099), TLR4 (rs4986790), TLR4 (rs4986791), IL1R (rs2234650), tumor necrosis factor (TNF)-α (rs1800629), TNF (rs361525), and IL1RN (rs315952) towards the development of HO in Saudi patients and compared to healthy controls.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “In this study, we investigated the contribution of SNPs in interleukin (IL)-1B1 (rs16944), IL1A (rs1800587), IL1B (rs1143634), toll-like receptor (TLR)-2 (rs3804099), TLR4 (rs4986790), TLR4 (rs4986791), IL1R (rs2234650), tumor necrosis factor (TNF)-α (rs1800629), TNF (rs361525), and IL1RN (rs315952) towards the development of HO in Saudi patients and compared to healthy controls.” | 0.98 | hgnc_dict_v1 |
Expression and Polymorphism of Toll-Like Receptor 4 and Effect on NF-κB Mediated Inflammation in Colon Cancer Patients.
PMID 26771524 | PMCID PMC4714746 | DOI 10.1371/journal.pone.0146333 · PloS one · 2016 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4986790 | “TLR4 (rs4986790, rs10759932, rs10759931 and rs2770150) were genotyped in blood samples from Colorectal patients and healthy controls.” | 0.90 | hgvs_regex_v1 |
| gene | TLR4 | “Our aim was to evaluate the association between the expression and the polymorphism of TLR4/NF-κB pathways and colon cancer.” | 0.98 | hgnc_dict_v1 |
| phenotype | colorectal cancer | “Expression and Polymorphism of Toll-Like Receptor 4 and Effect on NF-κB Mediated Inflammation in Colon Cancer Patients.” | 0.93 | phenotype_alias_lexicon_v2 |
| variant | rs10759932 | “TLR4 (rs4986790, rs10759932, rs10759931 and rs2770150) were genotyped in blood samples from Colorectal patients and healthy controls.” | 0.90 | hgvs_regex_v1 |
The association of toll-like receptor 4 polymorphism with hepatitis C virus infection in Saudi Arabian patients.
PMID 25177689 | PMCID PMC4142570 | DOI 10.1155/2014/357062 · BioMed research international · 2014 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4986790 | “Two SNPs in the TLR4 gene, rs4986790 (A/G) and rs4986791 (C/T), were genotyped in 450 HCV patients and 600 uninfected controls.” | 0.90 | hgvs_regex_v1 |
| gene | TLR4 | “A recent study reported that TLR4 gene polymorphisms are good prognostic predictors and are associated with protection from liver fibrosis among Caucasians.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatitis C | “The association of toll-like receptor 4 polymorphism with hepatitis C virus infection in Saudi Arabian patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | hepatocellular carcinoma | “It affects millions of people worldwide and is considered as a leading cause of liver diseases including cirrhosis and hepatocellular carcinoma.” | 0.98 | phenotype_alias_lexicon_v2 |
Genetic variation of TLR2 and TLR4 among the Saudi Arabian population: insight into the evolutionary dynamics of the Arabian Peninsula.
PMID 23289617 | DOI 10.1089/gtmb.2012.0281 · Genetic testing and molecular biomarkers · 2013 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4986790 | “Two polymorphisms located in the TLR2 gene (Pro631His and Arg753Gln, rs5743704 and rs5743708, respectively), and two (Asp299Gly and Thr399Ile, rs4986790 and rs4986791, respectively), located in the TLR4 gene have been genotyped in 201 unrelated individuals from Saudi Arabia.” | 0.90 | hgvs_regex_v1 |
| gene | TLR2 | “Genetic variation of TLR2 and TLR4 among the Saudi Arabian population: insight into the evolutionary dynamics of the Arabian Peninsula.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Genetic variation of TLR2 and TLR4 among the Saudi Arabian population: insight into the evolutionary dynamics of the Arabian Peninsula.” | 0.98 | hgnc_dict_v1 |
| phenotype | malaria | “Considering the reported protective role of these polymorphisms against malaria, the data suggest that the regional variation at these gene loci could have been shaped by both evolutionary infection pressure and bidirectional human migrations in the past.” | 0.98 | phenotype_alias_lexicon_v2 |