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4 records shown · first 60Effect of Pharmacogenetics on Renal Outcomes of Heart Failure Patients with Reduced Ejection Fraction (HFrEF) in Response to Dapagliflozin.
PMID 40870982 | PMCID PMC12389526 | DOI 10.3390/pharmaceutics17080959 · Pharmaceutics · 2025 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs5219 | “However, rs5219 (KCNJ11) showed no significant impact on renal outcomes.” | 0.90 | hgvs_regex_v1 |
| gene | SLC5A2 | “This study investigates the influence of genetic polymorphisms on renal outcomes in HFrEF patients treated with dapagliflozin, focusing on variations in genes such as SLC5A2, UMOD, KCNJ11, and ACE.” | 0.98 | hgnc_dict_v1 |
| gene | UMOD | “This study investigates the influence of genetic polymorphisms on renal outcomes in HFrEF patients treated with dapagliflozin, focusing on variations in genes such as SLC5A2, UMOD, KCNJ11, and ACE.” | 0.98 | hgnc_dict_v1 |
| gene | KCNJ11 | “This study investigates the influence of genetic polymorphisms on renal outcomes in HFrEF patients treated with dapagliflozin, focusing on variations in genes such as SLC5A2, UMOD, KCNJ11, and ACE.” | 0.98 | hgnc_dict_v1 |
Saudi Community-Based Screening Study on Genetic Variants in β-Cell Dysfunction and Its Role in Women with Gestational Diabetes Mellitus.
PMID 37107681 | PMCID PMC10137495 | DOI 10.3390/genes14040924 · Genes · 2023 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs5219 | “The purpose of this study was to investigate the genes associated with β-cell dysfunction and their genetic roles in the rs7903146, rs2237892, and rs5219 variants in Saudi women diagnosed with type 2 diabetes mellitus and GDM.” | 0.90 | hgvs_regex_v1 |
| gene | TCF7L2 | “TCF7L2, KCNQ1, and KCNJ11 genes are connected to the mechanism of β-cell dysfunction.” | 0.98 | hgnc_dict_v1 |
| gene | KCNQ1 | “TCF7L2, KCNQ1, and KCNJ11 genes are connected to the mechanism of β-cell dysfunction.” | 0.98 | hgnc_dict_v1 |
| gene | KCNJ11 | “TCF7L2, KCNQ1, and KCNJ11 genes are connected to the mechanism of β-cell dysfunction.” | 0.98 | hgnc_dict_v1 |
Significant variants of type 2 diabetes in the Arabian Region through an Integration of exome databases.
PMID 33848288 | PMCID PMC8043376 | DOI 10.1371/journal.pone.0249226 · PloS one · 2021 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs5219 | “After the integration, we obtained 18 single nucleotide polymorphisms and found two statistically and clinically significant variants in two genes, SLC30A8 rs13266634 and KCNJ11 rs5219.” | 0.90 | hgvs_regex_v1 |
| gene | SLC30A8 | “After the integration, we obtained 18 single nucleotide polymorphisms and found two statistically and clinically significant variants in two genes, SLC30A8 rs13266634 and KCNJ11 rs5219.” | 0.98 | hgnc_dict_v1 |
| gene | KCNJ11 | “After the integration, we obtained 18 single nucleotide polymorphisms and found two statistically and clinically significant variants in two genes, SLC30A8 rs13266634 and KCNJ11 rs5219.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Significant variants of type 2 diabetes in the Arabian Region through an Integration of exome databases.” | 0.93 | phenotype_alias_lexicon_v2 |
ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.
PMID 23458876 | DOI 10.1016/j.gene.2013.02.017 · Gene · 2013 · 20 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs5219 | “KCNJ11 rs5219 was significantly associated in both the populations with a pooled OR of 1.176(1.092-1.268), p<0.0001 and I(2)=32.40% in Caucasians and a pooled OR of 1.28(1.111-1.475), p=0.001 among Arabs.” | 0.90 | hgvs_regex_v1 |
| gene | ACE | “ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.” | 0.98 | hgnc_dict_v1 |
| gene | MTHFR | “ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.” | 0.98 | hgnc_dict_v1 |
| gene | TCF7L2 | “It was found that TCF7L2 rs7903146 was significantly associated with a pooled OR of 1.155 (95%C.I.=1.059-1.259), p<0.0001 and I(2)=78.30% among the Arab population, whereas among Caucasians, the pooled OR was 1.45 (95%C.I.=1.386-1.516), p<0.0001 and I(2)=77.20%.” | 0.98 | hgnc_dict_v1 |