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2 records shown · first 60Analysis of Toll-Like Receptor 2 Polymorphism (rs5743704) in Saudi Patients with Primary Open-Angle Glaucoma.
PMID 26866668 | DOI 10.1089/gtmb.2015.0310 · Genetic testing and molecular biomarkers · 2016 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs5743704 | “Analysis of Toll-Like Receptor 2 Polymorphism (rs5743704) in Saudi Patients with Primary Open-Angle Glaucoma.” | 0.90 | hgvs_regex_v1 |
| population | Saudi Arabia | “Analysis of Toll-Like Receptor 2 Polymorphism (rs5743704) in Saudi Patients with Primary Open-Angle Glaucoma. AIMS: To investigate whether the single-nucleotide polymorphism (SNP) rs5743704 in the toll-like receptor 2 gene is associated with primary open-angle glaucoma (POAG) or any of its clinical indices in a Saudi cohort. METHOD: Ninety-five unrelated POAG cases and 95 controls of Saudi origin were genotyped utilizing a TaqMan(®) assay. CONCLUSION: SNP rs5773704 is not associated with POAG in a Saudi population.” | 0.95 | saudi_context_rules_v1 |
| variant | rs5773704 | “CONCLUSION: SNP rs5773704 is not associated with POAG in a Saudi population.” | 0.90 | hgvs_regex_v1 |
Genetic variation of TLR2 and TLR4 among the Saudi Arabian population: insight into the evolutionary dynamics of the Arabian Peninsula.
PMID 23289617 | DOI 10.1089/gtmb.2012.0281 · Genetic testing and molecular biomarkers · 2013 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs5743704 | “Two polymorphisms located in the TLR2 gene (Pro631His and Arg753Gln, rs5743704 and rs5743708, respectively), and two (Asp299Gly and Thr399Ile, rs4986790 and rs4986791, respectively), located in the TLR4 gene have been genotyped in 201 unrelated individuals from Saudi Arabia.” | 0.90 | hgvs_regex_v1 |
| gene | TLR2 | “Genetic variation of TLR2 and TLR4 among the Saudi Arabian population: insight into the evolutionary dynamics of the Arabian Peninsula.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Genetic variation of TLR2 and TLR4 among the Saudi Arabian population: insight into the evolutionary dynamics of the Arabian Peninsula.” | 0.98 | hgnc_dict_v1 |
| phenotype | malaria | “Considering the reported protective role of these polymorphisms against malaria, the data suggest that the regional variation at these gene loci could have been shaped by both evolutionary infection pressure and bidirectional human migrations in the past.” | 0.98 | phenotype_alias_lexicon_v2 |