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4 records shown · first 60Serum levels of Wnt5a in Egyptian women with obesity and their association with toll like receptor 2 Arg753Gln gene polymorphism in a pilot case control study of obesity as a state of metaflammation.
PMID 39837875 | PMCID PMC11751074 | DOI 10.1038/s41598-025-85470-9 · Scientific reports · 2025 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs5743708 | “No significant differences were found in the distribution of TLR2 Arg753Gln (rs5743708) genotypes and alleles according to obesity or MetS, and the regression analysis showed no significant risk association.” | 0.90 | hgvs_regex_v1 |
| gene | TLR2 | “We aimed to assess the serum levels of wingless integration site family member 5 A (Wnt5a), leptin, and tumor necrosis factor-alpha (TNF-α) as markers of obesity-associated metaflammation and investigate the association with toll-like receptors2 (TLR2) gene (Arg753Gln) single nucleotide polymorphism (SNP) among Egyptian females.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Serum levels of Wnt5a in Egyptian women with obesity and their association with toll like receptor 2 Arg753Gln gene polymorphism in a pilot case control study of obesity as a state of metaflammation.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | metabolic syndrome | “Only TNF-α and leptin were associated with metabolic syndrome (MetS) among the obesity group.” | 0.98 | phenotype_alias_lexicon_v2 |
Association of TLR2 (rs5743708) Gene Polymorphism with Asthma Susceptibility and the Impact of Smoking: (Case-Control Study).
PMID 40996012 | DOI 10.7417/CT.2025.5275 · La Clinica terapeutica · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs5743708 | “Association of TLR2 (rs5743708) Gene Polymorphism with Asthma Susceptibility and the Impact of Smoking: (Case-Control Study).” | 0.90 | hgvs_regex_v1 |
| gene | TLR2 | “Association of TLR2 (rs5743708) Gene Polymorphism with Asthma Susceptibility and the Impact of Smoking: (Case-Control Study).” | 0.98 | hgnc_dict_v1 |
| phenotype | asthma | “Association of TLR2 (rs5743708) Gene Polymorphism with Asthma Susceptibility and the Impact of Smoking: (Case-Control Study).” | 0.98 | phenotype_alias_lexicon_v2 |
A study on the immunological vitality of an inflammatory biomarker explored with rs5743708 polymorphism in TLR2 gene among Saudi women confirmed with polycystic ovarian syndrome.
PMID 37485450 | PMCID PMC10362453 | DOI 10.1016/j.sjbs.2023.103687 · Saudi journal of biological sciences · 2023 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs5743708 | “A study on the immunological vitality of an inflammatory biomarker explored with rs5743708 polymorphism in TLR2 gene among Saudi women confirmed with polycystic ovarian syndrome.” | 0.90 | hgvs_regex_v1 |
| gene | TLR2 | “A study on the immunological vitality of an inflammatory biomarker explored with rs5743708 polymorphism in TLR2 gene among Saudi women confirmed with polycystic ovarian syndrome.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Toll-like receptor 2 (TLR2) gene was linked to PCOS and chronic inflammation, and the prevalence of obesity was rising in Saudi women.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “A study on the immunological vitality of an inflammatory biomarker explored with rs5743708 polymorphism in TLR2 gene among Saudi women confirmed with polycystic ovarian syndrome. Toll-like receptor 2 (TLR2) gene was linked to PCOS and chronic inflammation, and the prevalence of obesity was rising in Saudi women. AIM: In this study, we investigated the molecular role of rs5743708 polymorphism in TLR2 gene among Saudi women diagnosed with PCOS using the Rotterdam criteria. METHODS: Blood samples were collected from 220 Saudi women in this hospital-based case-control study; 110 were PCOS women and remaining 110 were non-PCOS (control women). CONCLUSION: The rs5743708 polymorphism was not associated to PCOS in Saudi women.” | 0.95 | saudi_context_rules_v1 |
Genetic variation of TLR2 and TLR4 among the Saudi Arabian population: insight into the evolutionary dynamics of the Arabian Peninsula.
PMID 23289617 | DOI 10.1089/gtmb.2012.0281 · Genetic testing and molecular biomarkers · 2013 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs5743708 | “Two polymorphisms located in the TLR2 gene (Pro631His and Arg753Gln, rs5743704 and rs5743708, respectively), and two (Asp299Gly and Thr399Ile, rs4986790 and rs4986791, respectively), located in the TLR4 gene have been genotyped in 201 unrelated individuals from Saudi Arabia.” | 0.90 | hgvs_regex_v1 |
| gene | TLR2 | “Genetic variation of TLR2 and TLR4 among the Saudi Arabian population: insight into the evolutionary dynamics of the Arabian Peninsula.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Genetic variation of TLR2 and TLR4 among the Saudi Arabian population: insight into the evolutionary dynamics of the Arabian Peninsula.” | 0.98 | hgnc_dict_v1 |
| phenotype | malaria | “Considering the reported protective role of these polymorphisms against malaria, the data suggest that the regional variation at these gene loci could have been shaped by both evolutionary infection pressure and bidirectional human migrations in the past.” | 0.98 | phenotype_alias_lexicon_v2 |