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1 records shown · first 60Unveiling hidden risks: pharmacogenetic insights from a cross-sectional study of statin therapy in the Indian population.
PMID 40489054 | DOI 10.1007/s43440-025-00746-1 · Pharmacological reports : PR · 2025 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs71581988 | “Two rare SLCO1B1 variants in SLCO1B1 i.e., rs201722521 and rs71581988, were reported to affect the binding affinity of certain statins.” | 0.90 | hgvs_regex_v1 |
| gene | SLCO1B1 | “Hence, we conducted a population-level screening for pharmacogenetic determinants of statin therapy, particularly Solute Carrier Organic Anion Transporter Family Member 1B1 (SLCO1B1) and ATP-binding cassette sub-family G member 2 (ABCG2).” | 0.98 | hgnc_dict_v1 |
| gene | ABCG2 | “Hence, we conducted a population-level screening for pharmacogenetic determinants of statin therapy, particularly Solute Carrier Organic Anion Transporter Family Member 1B1 (SLCO1B1) and ATP-binding cassette sub-family G member 2 (ABCG2).” | 0.98 | hgnc_dict_v1 |
| phenotype | dyslipidemia | “BACKGROUND: Statin usage has increased significantly in India due to the very high incidence of dyslipidemia, however, approximately 18% of the population is at risk for statin-induced myopathy.” | 0.98 | phenotype_alias_lexicon_v2 |