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2 records shown · first 60Association between tobacco substance usage and a missense mutation in the tumor suppressor gene P53 in the Saudi Arabian population.
PMID 33481818 | PMCID PMC7822264 | DOI 10.1371/journal.pone.0245133 · PloS one · 2021 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs769412 | “P53 rs1042522 (C/G), P21 rs1801270 (A/C), and MDM2 rs769412 (A/G) were investigated by genotyping 568 blood specimens: 283 from male/female smokers and 285 from male/female non-smokers.” | 0.90 | hgvs_regex_v1 |
| gene | TP53 | “The tumor suppressor gene TP53 and its downstream genes P21 and MDM2 play crucial roles in combating DNA damage at the G1/S cell cycle checkpoint.” | 0.98 | hgnc_dict_v1 |
| gene | MDM2 | “The tumor suppressor gene TP53 and its downstream genes P21 and MDM2 play crucial roles in combating DNA damage at the G1/S cell cycle checkpoint.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia | “Association between tobacco substance usage and a missense mutation in the tumor suppressor gene P53 in the Saudi Arabian population. This study was conducted to examine a potential association between tobacco substance usage (TSU) and single-nucleotide polymorphism (SNP) at the exon regions of the P53, P21, and MDM2 genes by comparing populations of smokers and non-smokers from Saudi Arabia. Heterozygous CG, homozygous GG, and CG+GG genotypes, as well as the G allele of rs1042522 were significantly associated with TSU in Saudi smokers compared with non-smokers. The selected SNP of P53 was strongly associated with TSU and may be linked to TSU-induced diseases in the Saudi Arabian population.” | 0.95 | saudi_context_rules_v1 |
MDM2 (RS769412) G>A Polymorphism in Cigarette Smokers: a Clue for the Susceptibility to Smoking and Lung Cancer Risk.
PMID 25987086 | DOI 10.7314/apjcp.2015.16.9.4057 · Asian Pacific journal of cancer prevention : APJCP · 2015 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | RS769412 | “MDM2 (RS769412) G>A Polymorphism in Cigarette Smokers: a Clue for the Susceptibility to Smoking and Lung Cancer Risk.” | 0.90 | hgvs_regex_v1 |
| gene | MDM2 | “MDM2 (RS769412) G>A Polymorphism in Cigarette Smokers: a Clue for the Susceptibility to Smoking and Lung Cancer Risk.” | 0.98 | hgnc_dict_v1 |
| phenotype | lung cancer | “MDM2 (RS769412) G>A Polymorphism in Cigarette Smokers: a Clue for the Susceptibility to Smoking and Lung Cancer Risk.” | 0.98 | phenotype_alias_lexicon_v2 |