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2 records shown · first 60Bleeding Events Associated with Rivaroxaban Therapy in Naive Patients with Nonvalvular Atrial Fibrillation: A Longitudinal Study from a Genetic Perspective with INR Follow-Up.
PMID 39459499 | PMCID PMC11509751 | DOI 10.3390/medicina60101712 · Medicina (Kaunas, Lithuania) · 2024 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs776746 | “Results: The heterozygous and homozygous mutant genotypes of ABCB1 (rs2032582, rs1045642, rs1128503, and rs4148738) and CYP3A5 (rs776746) showed lower plasma concentrations as compared to the wild-type genotype.” | 0.90 | hgvs_regex_v1 |
| gene | ABCB1 | “Rivaroxaban is a substrate for P-glycoprotein, which is encoded by the ABCB1 gene.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A5 | “Rivaroxaban is also metabolized by the CYP3A5 gene.” | 0.98 | hgnc_dict_v1 |
| phenotype | stroke | “Background and Objectives: Rivaroxaban is a direct-acting anticoagulant used to prevent stroke in patients with atrial fibrillation.” | 0.98 | phenotype_alias_lexicon_v2 |
Association of cytochromes P450 3A4*22 and 3A5*3 genotypes and polymorphism with response to simvastatin in hypercholesterolemia patients.
PMID 35839255 | PMCID PMC9286239 | DOI 10.1371/journal.pone.0260824 · PloS one · 2022 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs776746 | “This study aimed to investigate the association of CYP3A4*22 (rs35599367), CYP3A5*3 (rs776746) single nucleotide polymorphism (SNP) with response to simvastatin in hypercholesterolemia patients conducted at King Abdulaziz University hospital (KAUH) in Jeddah, Saudi Arabia.” | 0.90 | hgvs_regex_v1 |
| gene | CYP3A4 | “This study aimed to investigate the association of CYP3A4*22 (rs35599367), CYP3A5*3 (rs776746) single nucleotide polymorphism (SNP) with response to simvastatin in hypercholesterolemia patients conducted at King Abdulaziz University hospital (KAUH) in Jeddah, Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A5 | “This study aimed to investigate the association of CYP3A4*22 (rs35599367), CYP3A5*3 (rs776746) single nucleotide polymorphism (SNP) with response to simvastatin in hypercholesterolemia patients conducted at King Abdulaziz University hospital (KAUH) in Jeddah, Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| phenotype | familial hypercholesterolemia | “Association of cytochromes P450 3A4*22 and 3A5*3 genotypes and polymorphism with response to simvastatin in hypercholesterolemia patients.” | 0.93 | phenotype_alias_lexicon_v2 |