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9 records shown · first 60Molecular Characterization and Impact of the Genetic Variants GSTP1, LncRNA H19, TCF7L2 and HNF1A on the Risk of Coronary Artery Disease With and Without T2DM Comorbidity: A Genomic Biomarker Study.
PMID 40485517 | DOI 10.24976/Discov.Med.202537197.89 · Discovery medicine · 2025 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs7903146 | “Given the strong genetic basis underlying the pathogenesis of T2DM and CAD, this study aimed to investigate the potential significance of the following genetic variants in the pathogenesis of CAD with and without T2DM comorbidity: hepatocyte nuclear factor-1 alpha (HNF1A) [p.I27L] rs1169288, glutathione S-transferase Pi 1 (GSTP1) rs1695 (A>G; Ile→Val), transcription factor 7-like 2 (TCF7L2) rs7903146 (C>T), and long non-coding RNA H19 (LncRNA H19) rs217727 (C>T).” | 0.90 | hgvs_regex_v1 |
| gene | GSTP1 | “Molecular Characterization and Impact of the Genetic Variants GSTP1, LncRNA H19, TCF7L2 and HNF1A on the Risk of Coronary Artery Disease With and Without T2DM Comorbidity: A Genomic Biomarker Study.” | 0.98 | hgnc_dict_v1 |
| gene | H19 | “Molecular Characterization and Impact of the Genetic Variants GSTP1, LncRNA H19, TCF7L2 and HNF1A on the Risk of Coronary Artery Disease With and Without T2DM Comorbidity: A Genomic Biomarker Study.” | 0.98 | hgnc_dict_v1 |
| gene | TCF7L2 | “Molecular Characterization and Impact of the Genetic Variants GSTP1, LncRNA H19, TCF7L2 and HNF1A on the Risk of Coronary Artery Disease With and Without T2DM Comorbidity: A Genomic Biomarker Study.” | 0.98 | hgnc_dict_v1 |
Interaction between the TCF7L2 gene and dietary intake on metabolic syndrome risk factors among Saudi Arabian adults.
PMID 40170676 | PMCID PMC11960299 | DOI 10.3389/fnut.2025.1513088 · Frontiers in nutrition · 2025 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs7903146 | “The single-nucleotide polymorphism (SNP) rs7903146 in TCF7L2 in T2D interacts with dietary factors; however, research on nutrigenetics among Saudi Arabians is limited.” | 0.90 | hgvs_regex_v1 |
| gene | TCF7L2 | “Interaction between the TCF7L2 gene and dietary intake on metabolic syndrome risk factors among Saudi Arabian adults.” | 0.98 | hgnc_dict_v1 |
| phenotype | metabolic syndrome | “Interaction between the TCF7L2 gene and dietary intake on metabolic syndrome risk factors among Saudi Arabian adults.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | obesity | “METHODS: This cross-sectional study included 271 adult participants (aged 20-55 years) of both genders with or without overweight or obesity (body mass index between 18-35 kg/m2).” | 0.98 | phenotype_alias_lexicon_v2 |
Saudi Community-Based Screening Study on Genetic Variants in β-Cell Dysfunction and Its Role in Women with Gestational Diabetes Mellitus.
PMID 37107681 | PMCID PMC10137495 | DOI 10.3390/genes14040924 · Genes · 2023 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs7903146 | “The purpose of this study was to investigate the genes associated with β-cell dysfunction and their genetic roles in the rs7903146, rs2237892, and rs5219 variants in Saudi women diagnosed with type 2 diabetes mellitus and GDM.” | 0.90 | hgvs_regex_v1 |
| gene | TCF7L2 | “TCF7L2, KCNQ1, and KCNJ11 genes are connected to the mechanism of β-cell dysfunction.” | 0.98 | hgnc_dict_v1 |
| gene | KCNQ1 | “TCF7L2, KCNQ1, and KCNJ11 genes are connected to the mechanism of β-cell dysfunction.” | 0.98 | hgnc_dict_v1 |
| gene | KCNJ11 | “TCF7L2, KCNQ1, and KCNJ11 genes are connected to the mechanism of β-cell dysfunction.” | 0.98 | hgnc_dict_v1 |
Associations of transcription factor 7-Like 2 (TCF7L2) gene polymorphism in patients of type 2 diabetes mellitus from Khyber Pakhtunkhwa population of Pakistan.
PMID 34394276 | PMCID PMC8356593 | DOI 10.4314/ahs.v21i1.4 · African health sciences · 2021 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs7903146 | “Genomic DNA was extracted and genotype of common variants (rs7903146 C/T and rs12255372 G/T) was carried out by amplification-refractory mutation system (ARMS)-PCR of sequence specific oligonucleotides.” | 0.90 | hgvs_regex_v1 |
| gene | TCF7L2 | “Associations of transcription factor 7-Like 2 (TCF7L2) gene polymorphism in patients of type 2 diabetes mellitus from Khyber Pakhtunkhwa population of Pakistan.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Associations of transcription factor 7-Like 2 (TCF7L2) gene polymorphism in patients of type 2 diabetes mellitus from Khyber Pakhtunkhwa population of Pakistan.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | metabolic syndrome | “BACKGROUND: Type 2 diabetes mellitus (T2DM) is the most prevalent component of metabolic syndrome.” | 0.98 | phenotype_alias_lexicon_v2 |
Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide.
PMID 38487510 | PMCID PMC10904069 | DOI 10.34133/2021/9897048 · Health data science · 2021 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs7903146 | “The strongest locus which associated with type 2 diabetes (T2D) by the common variant rs7903146 is the transcription factor 7-like 2 gene (TCF7L2).” | 0.90 | hgvs_regex_v1 |
| gene | TCF7L2 | “Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | diabetes mellitus | “The strongest locus which associated with type 2 diabetes (T2D) by the common variant rs7903146 is the transcription factor 7-like 2 gene (TCF7L2).” | 0.93 | phenotype_alias_lexicon_v2 |
Type 2 diabetes mellitus susceptibility gene TCF7L2 is strongly associated with hyperglycemia in the Saudi Arabia Population of the eastern province of Saudi Arabia.
PMID 26367734 · European review for medical and pharmacological sciences · 2015 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs7903146 | “OBJECTIVE: We studied the association of single nucleotide polymorphisms (SNPs) rs7903146, rs12255372 and rs4506565 in type 2 diabetes mellitus (T2DM) susceptibility gene, transcription factor 7 like 2 (TCF7L2) with T2DM among the population of the Eastern Province of Saudi Arabia.” | 0.90 | hgvs_regex_v1 |
| gene | TCF7L2 | “Type 2 diabetes mellitus susceptibility gene TCF7L2 is strongly associated with hyperglycemia in the Saudi Arabia Population of the eastern province of Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Type 2 diabetes mellitus susceptibility gene TCF7L2 is strongly associated with hyperglycemia in the Saudi Arabia Population of the eastern province of Saudi Arabia.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia, Eastern Province | “Type 2 diabetes mellitus susceptibility gene TCF7L2 is strongly associated with hyperglycemia in the Saudi Arabia Population of the eastern province of Saudi Arabia. OBJECTIVE: We studied the association of single nucleotide polymorphisms (SNPs) rs7903146, rs12255372 and rs4506565 in type 2 diabetes mellitus (T2DM) susceptibility gene, transcription factor 7 like 2 (TCF7L2) with T2DM among the population of the Eastern Province of Saudi Arabia. PATIENTS AND METHODS: In a case-control study, blood samples were collected from 359 T2DM patients and 351 age and sex-matched normoglycemic controls. RESULTS: Our results revealed a strong association between risk T alleles in variants rs12255372 (OR: G/T=1.4233; T/T=2.0395) and rs4506565 (OR: A/T=1.6066; T/T=3.1301) and T2DM among the Saudi population of the Eastern Province of Saudi Arabia. This is the first time that this association has been identified in a Saudi population. These data further strengthens the hypothesis that Saudi populations might carry a distinct risk allele in T2DM susceptibility gene TCF7L2. CONCLUSIONS: The present results confirm that rs12255372 and rs4506565 variants of TCF7L2 show an association, but not rs7903146, with T2DM for the Saudi population of the Eastern Province of Saudi Arabia.” | 0.95 | saudi_context_rules_v1 |
Association between type 2 diabetes mellitus-related SNP variants and obesity traits in a Saudi population.
PMID 24435973 | DOI 10.1007/s11033-014-3022-z · Molecular biology reports · 2014 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs7903146 | “Variants of SNPs rs7903146, rs1552224 and rs11642841 in the control group and rs7903146 in T2DM group showed significant association with both BMI and WC.” | 0.90 | hgvs_regex_v1 |
| phenotype | obesity | “Association between type 2 diabetes mellitus-related SNP variants and obesity traits in a Saudi population.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | diabetes mellitus | “Association between type 2 diabetes mellitus-related SNP variants and obesity traits in a Saudi population.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Association between type 2 diabetes mellitus-related SNP variants and obesity traits in a Saudi population. In addition to the environmental factors, genetic factors may also contribute to the ongoing obesity epidemic in Saudi Arabia. This study investigated the association between variants of 36 previously established T2DM SNPs and obesity phenotypes in a population of Saudi subjects. Study subjects consisted of 975 obese (BMI: ≥30), 825 overweight (25-30) and 423 lean controls (18-25) and of these 927 had a history of T2DM.” | 0.95 | saudi_context_rules_v1 |
ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.
PMID 23458876 | DOI 10.1016/j.gene.2013.02.017 · Gene · 2013 · 20 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs7903146 | “It was found that TCF7L2 rs7903146 was significantly associated with a pooled OR of 1.155 (95%C.I.=1.059-1.259), p<0.0001 and I(2)=78.30% among the Arab population, whereas among Caucasians, the pooled OR was 1.45 (95%C.I.=1.386-1.516), p<0.0001 and I(2)=77.20%.” | 0.90 | hgvs_regex_v1 |
| gene | ACE | “ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.” | 0.98 | hgnc_dict_v1 |
| gene | MTHFR | “ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.” | 0.98 | hgnc_dict_v1 |
| gene | TCF7L2 | “It was found that TCF7L2 rs7903146 was significantly associated with a pooled OR of 1.155 (95%C.I.=1.059-1.259), p<0.0001 and I(2)=78.30% among the Arab population, whereas among Caucasians, the pooled OR was 1.45 (95%C.I.=1.386-1.516), p<0.0001 and I(2)=77.20%.” | 0.98 | hgnc_dict_v1 |
Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.
PMID 18655717 | PMCID PMC2515290 | DOI 10.1186/1471-2350-9-72 · BMC medical genetics · 2008 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs7903146 | “BACKGROUND: The rs7903146 and rs12255372 variants of TCF7L2 have been strongly associated with type 2 diabetes (T2D) risk in most populations studied to date.” | 0.90 | hgvs_regex_v1 |
| gene | TCF7L2 | “Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “METHODS: We performed a case-control association study using 522 Saudi T2D patients (WHO criteria), and 346 controls (age > 60; fasting plasma glucose < 7 mmol/L).” | 0.95 | saudi_context_rules_v1 |