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4 records shown · first 60The influence of polymorphisms in the drug transporter, ABCB1 on the toxicity of glucocorticoids in Saudi children with acute lymphoblastic leukaemia.
PMID 30508724 | DOI 10.1016/j.pharep.2018.09.010 · Pharmacological reports : PR · 2019 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | C3435T | “METHODS: Three single nucleotide polymorphisms (SNPs) of the ABCB1 gene (rs 3213619 T129C, rs 2032582 G2677T and rs1045642 C3435T) were analysed in 70 Saudi children with ALL and 60 control subjects.” | 0.82 | literature_variant_regex_v2 |
| gene | ABCB1 | “The influence of polymorphisms in the drug transporter, ABCB1 on the toxicity of glucocorticoids in Saudi children with acute lymphoblastic leukaemia.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “The influence of polymorphisms in the drug transporter, ABCB1 on the toxicity of glucocorticoids in Saudi children with acute lymphoblastic leukaemia.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “The influence of polymorphisms in the drug transporter, ABCB1 on the toxicity of glucocorticoids in Saudi children with acute lymphoblastic leukaemia. This study, the first of its kind in a Saudi population, investigates associations of ABCB1 gene polymorphisms (pharmacodynamics and pharmacokinetic) with the development of toxicity and side effects (glucose abnormality, liver toxicity and infection) in a small population of Saudi children with ALL. METHODS: Three single nucleotide polymorphisms (SNPs) of the ABCB1 gene (rs 3213619 T129C, rs 2032582 G2677T and rs1045642 C3435T) were analysed in 70 Saudi children with ALL and 60 control subjects.” | 0.95 | saudi_context_rules_v1 |
ABCB1 variants C3435T and T129C are not associated with colorectal cancer risk.
PMID 32127820 | PMCID PMC7040265 | DOI 10.4314/ahs.v19i3.23 · African health sciences · 2019 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | C3435T | “ABCB1 variants C3435T and T129C are not associated with colorectal cancer risk.” | 0.82 | literature_variant_regex_v2 |
| gene | ABCB1 | “ABCB1 variants C3435T and T129C are not associated with colorectal cancer risk.” | 0.98 | hgnc_dict_v1 |
| phenotype | colorectal cancer | “ABCB1 variants C3435T and T129C are not associated with colorectal cancer risk.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “BACKGROUND: Colorectal cancer (CRC) is one of the most prevalent cancers in Saudi Arabia that is highly characterized with poor survival rate and advanced metastasis. METHODS: 125 subjects (62 CRC patients and 63 healthy controls) were involved.” | 0.95 | saudi_context_rules_v1 |
Genetic variability and haplotype profile of MDR1 in Saudi Arabian males.
PMID 23053935 | DOI 10.1007/s11033-012-1906-3 · Molecular biology reports · 2012 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | C3435T | “In this study, we determined the frequencies of the most common three polymorphisms in the MDR1 gene (i.e., C1236T, G2677T, and C3435T) in Saudi Arabians and their haplotypes.” | 0.82 | literature_variant_regex_v2 |
| population | Saudi Arabia | “Genetic variability and haplotype profile of MDR1 in Saudi Arabian males. In this study, we determined the frequencies of the most common three polymorphisms in the MDR1 gene (i.e., C1236T, G2677T, and C3435T) in Saudi Arabians and their haplotypes. These identified frequencies in Saudi Arabians are different from that reported in the other ethnic groups.” | 0.95 | saudi_context_rules_v1 |
| variant | C1236T | “In this study, we determined the frequencies of the most common three polymorphisms in the MDR1 gene (i.e., C1236T, G2677T, and C3435T) in Saudi Arabians and their haplotypes.” | 0.82 | literature_variant_regex_v2 |
| variant | G2677T | “In this study, we determined the frequencies of the most common three polymorphisms in the MDR1 gene (i.e., C1236T, G2677T, and C3435T) in Saudi Arabians and their haplotypes.” | 0.82 | literature_variant_regex_v2 |
MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity.
PMID 11337937 | DOI 10.1097/00008571-200104000-00005 · Pharmacogenetics · 2001 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | C3435T | “MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity.” | 0.82 | literature_variant_regex_v2 |
| gene | PGP | “P-glycoprotein (PGP), the product of the multidrug resistance gene (MDR1), acts as an energy-dependent efflux pump that exports its substrates out of the cell.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia | “To facilitate clinical application throughout the world, 1280 subjects from 10 different ethnic groups were evaluated for this SNP using the polymerase chain reaction-restriction fragment length polymorphism assay and the genotype and allele frequency for each group were ascertained. The British Caucasian, Portuguese, South-west Asian, Chinese, Filipino and Saudi populations had lower frequencies of the C allele compared to the African group (48%, 43%, 34%, 53%, 59%, and 55%, respectively).” | 0.95 | saudi_context_rules_v1 |