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2 records shown · first 60Role of NQO1 Gene Involvement and Susceptibility of T2DM Among Saudi Arabia Population.
PMID 38959119 | DOI 10.1089/rej.2024.0032 · Rejuvenation research · 2024 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | C609T | “Therefore, the present research aimed to evaluate the genetic abnormality of NQO1 (rs1800566, C609T) gene polymorphism, expression, and vitamin-D level assessment among Type 2 diabetes mellitus (T2DM) patients.” | 0.82 | literature_variant_regex_v2 |
| gene | NQO1 | “Role of NQO1 Gene Involvement and Susceptibility of T2DM Among Saudi Arabia Population.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “NQO1 disruption enhances susceptibility to oxidative stress during hyperglycemia and is a significant contributor to the development and progression of diabetes.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | hypertension | “Oxidative stress has been linked to several symptoms, including hyperglycemia, reactive oxygen species buildup, high blood pressure, and the expression of inflammatory markers.” | 0.93 | phenotype_alias_lexicon_v2 |
Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population.
PMID 18601742 | PMCID PMC2492854 | DOI 10.1186/1471-2350-9-61 · BMC medical genetics · 2008 · 14 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | C609T | “METHODS: 223 incident papillary thyroid cancer cases and 513 controls recruited from Saudi Arabian population were analyzed for the association between polymorphisms in genes encoding folic acid metabolizing enzymes MTHFR and six xenobiotics-metabolizing enzymes including CYP1A1 T3801C, C4887A, GSTP1 A1578G, C2293T, GSTM1, GSTT1, NAT2 G590A, NQO*1 C609T, using PCR-RELP.” | 0.82 | literature_variant_regex_v2 |
| gene | MTHFR | “METHODS: 223 incident papillary thyroid cancer cases and 513 controls recruited from Saudi Arabian population were analyzed for the association between polymorphisms in genes encoding folic acid metabolizing enzymes MTHFR and six xenobiotics-metabolizing enzymes including CYP1A1 T3801C, C4887A, GSTP1 A1578G, C2293T, GSTM1, GSTT1, NAT2 G590A, NQO*1 C609T, using PCR-RELP.” | 0.98 | hgnc_dict_v1 |
| gene | CYP1A1 | “METHODS: 223 incident papillary thyroid cancer cases and 513 controls recruited from Saudi Arabian population were analyzed for the association between polymorphisms in genes encoding folic acid metabolizing enzymes MTHFR and six xenobiotics-metabolizing enzymes including CYP1A1 T3801C, C4887A, GSTP1 A1578G, C2293T, GSTM1, GSTT1, NAT2 G590A, NQO*1 C609T, using PCR-RELP.” | 0.98 | hgnc_dict_v1 |
| gene | GSTP1 | “METHODS: 223 incident papillary thyroid cancer cases and 513 controls recruited from Saudi Arabian population were analyzed for the association between polymorphisms in genes encoding folic acid metabolizing enzymes MTHFR and six xenobiotics-metabolizing enzymes including CYP1A1 T3801C, C4887A, GSTP1 A1578G, C2293T, GSTM1, GSTT1, NAT2 G590A, NQO*1 C609T, using PCR-RELP.” | 0.98 | hgnc_dict_v1 |