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6 records shown · first 60Impacts of circulating cytokine levels and gene polymorphism predisposition on type 1 diabetes mellitus.
PMID 39231486 | PMCID PMC11374510 | DOI 10.6065/apem.2346178.089 · Annals of pediatric endocrinology & metabolism · 2024 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800795 | “RESULTS: The levels of 3 circulating cytokines (transforming growth factor [TGF]-β1, interleukin [IL]-10, and IL-6) and 6 SNPs in 3 cytokine genes (TGF-β1 [rs1800470 and rs1800471], IL-10 [rs1800896, rs1800871, and rs1800872], and IL-6 [rs1800795]) that contribute to genetic susceptibility were measured by enzyme-linked immunosorbent assay and polymerase chain reaction with sequence-specific primers.” | 0.90 | hgvs_regex_v1 |
| phenotype | diabetes mellitus | “Impacts of circulating cytokine levels and gene polymorphism predisposition on type 1 diabetes mellitus.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “The aim of this study was to investigate the roles of cytokine levels and the association of single-nucleotide polymorphisms (SNPs) within cytokine genes with T1DM in Saudi children. Moreover, our data demonstrated no appreciable diferences in circulating serum level or genotype and phenotype of IL- 10 between the patients and controls. CONCLUSION: This kind of measurement, which considers the prediction of T1DM, may be useful in assessing the severity of T1DM and susceptibility to T1DM among Saudi children.” | 0.95 | saudi_context_rules_v1 |
| variant | rs1800470 | “RESULTS: The levels of 3 circulating cytokines (transforming growth factor [TGF]-β1, interleukin [IL]-10, and IL-6) and 6 SNPs in 3 cytokine genes (TGF-β1 [rs1800470 and rs1800471], IL-10 [rs1800896, rs1800871, and rs1800872], and IL-6 [rs1800795]) that contribute to genetic susceptibility were measured by enzyme-linked immunosorbent assay and polymerase chain reaction with sequence-specific primers.” | 0.90 | hgvs_regex_v1 |
Significant association between insulin-like growth factor 2 mRNA-binding protein 2, interleukin-6 polymorphisms, and type 2 diabetes mellitus.
PMID 39764221 | PMCID PMC11702346 | DOI 10.4103/jrms.jrms_717_23 · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800795 | “RESULTS: The results indicated that the mutant C-allele of the single nucleotide polymorphism (SNP) rs1800795 variant was highly significantly associated with the study group (P = 0.002).” | 0.90 | hgvs_regex_v1 |
| gene | IGF2BP2 | “BACKGROUND: The study aimed to detect the association between insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and interleukin-6 (IL-6) polymorphisms among type 2 diabetes mellitus (T2DM).” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Significant association between insulin-like growth factor 2 mRNA-binding protein 2, interleukin-6 polymorphisms, and type 2 diabetes mellitus.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “MATERIALS AND METHODS: This study involved 500 individuals; 250 obese DM cases and 250 healthy controls. CONCLUSION: The current study indicated that IGF2BP2 rs4402960 and IL-6 rs1800795 polymorphism were highly significantly associated with the increased risk of obese T2DM among the Saudi Arabian population and presented a genetic model to screen the high-risk individuals with further validations.” | 0.95 | saudi_context_rules_v1 |
Association of Alzheimer's Disease with Genetic Variants of Apolipoprotein E, Clusterin, TNF-α, and IL-6 Among Elderly Saudis.
PMID 35135450 | DOI 10.2174/1389201023666220208093919 · Current pharmaceutical biotechnology · 2022 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800795 | “METHODS: A total of 42 Saudi AD patients and 23 age-matched control participants were genotyped for eight SNPs: rs429358, rs7412 (ApoE); rs11136000, rs1532278 (CLU); rs1800629, rs1799724 (TNF-α) and rs1800796, rs1800795(IL-6), by RT-PCR using the TaqMan assay.” | 0.90 | hgvs_regex_v1 |
| gene | CLU | “OBJECTIVES: To investigate the association of Single Nucleotide Polymorphisms (SNPs) in apolipoprotein E (ApoE), clusterin (CLU), tumor necrotic factor- α (TNF-α) and interleukin-6 (IL-6) genes, with risk of Alzheimer's disease (AD) in Saudi Arabian participants.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Association of Alzheimer's Disease with Genetic Variants of Apolipoprotein E, Clusterin, TNF-α, and IL-6 Among Elderly Saudis.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “OBJECTIVES: To investigate the association of Single Nucleotide Polymorphisms (SNPs) in apolipoprotein E (ApoE), clusterin (CLU), tumor necrotic factor- α (TNF-α) and interleukin-6 (IL-6) genes, with risk of Alzheimer's disease (AD) in Saudi Arabian participants. METHODS: A total of 42 Saudi AD patients and 23 age-matched control participants were genotyped for eight SNPs: rs429358, rs7412 (ApoE); rs11136000, rs1532278 (CLU); rs1800629, rs1799724 (TNF-α) and rs1800796, rs1800795(IL-6), by RT-PCR using the TaqMan assay. CONCLUSION: Genetic variants in ApoE and CLU may influence susceptibility to AD among Saudi Arabian participants.” | 0.95 | saudi_context_rules_v1 |
Association of IL-6 promoter polymorphism hotspots (- 174G/C and - 572G/C) with cardiovascular disease risk factors.
PMID 35023009 | DOI 10.1007/s11033-021-07048-8 · Molecular biology reports · 2022 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800795 | “We observed a statistically significant association (p < 0.05) between GG (66.29%), GC (30.34%), and CC (3.37%) genotypes at the - 174G/C (rs1800795) hotspot and neopterin levels.” | 0.90 | hgvs_regex_v1 |
| phenotype | hypertension | “However, the genotypes at the - 572G/C (rs1800796) hotspot did not show any association with age, gender, obesity, diabetes, hypertension, dyslipidemia, smoking, and coronary artery status.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | obesity | “However, the genotypes at the - 572G/C (rs1800796) hotspot did not show any association with age, gender, obesity, diabetes, hypertension, dyslipidemia, smoking, and coronary artery status.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | dyslipidemia | “However, the genotypes at the - 572G/C (rs1800796) hotspot did not show any association with age, gender, obesity, diabetes, hypertension, dyslipidemia, smoking, and coronary artery status.” | 0.98 | phenotype_alias_lexicon_v2 |
Interleukin-6 gene polymorphism in Saudi population with recurrent aphthous stomatitis.
PMID 34938040 | PMCID PMC8665156 | DOI 10.1016/j.sdentj.2021.07.007 · The Saudi dental journal · 2021 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | Rs1800795 | “Polymorphisms of Rs1800795 heterozygous genotype were found in 21.62% of cases, and 33.33% of controls.” | 0.90 | hgvs_regex_v1 |
| population | Saudi Arabia | “Interleukin-6 gene polymorphism in Saudi population with recurrent aphthous stomatitis. METHODOLOGY: A total of 37 RAS patients and 18 healthy controls were included in the study.” | 0.95 | saudi_context_rules_v1 |
Association between Hepatitis C Virus Viremia and the rs12979860, rs2228145 and rs1800795 SNP (CT/AC/GG) Genotype in Saudi Kidney Transplant Recipients.
PMID 31929778 | PMCID PMC6945315 | DOI 10.4103/sjmms.sjmms_175_18 · Saudi journal of medicine & medical sciences · 2020 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800795 | “Association between Hepatitis C Virus Viremia and the rs12979860, rs2228145 and rs1800795 SNP (CT/AC/GG) Genotype in Saudi Kidney Transplant Recipients.” | 0.90 | hgvs_regex_v1 |
| phenotype | hepatitis C | “Association between Hepatitis C Virus Viremia and the rs12979860, rs2228145 and rs1800795 SNP (CT/AC/GG) Genotype in Saudi Kidney Transplant Recipients.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Association between Hepatitis C Virus Viremia and the rs12979860, rs2228145 and rs1800795 SNP (CT/AC/GG) Genotype in Saudi Kidney Transplant Recipients. RESULTS: HCV RNA was detected in 17 (11.41%) of the 149 patients.” | 0.95 | saudi_context_rules_v1 |
| variant | rs12979860 | “Association between Hepatitis C Virus Viremia and the rs12979860, rs2228145 and rs1800795 SNP (CT/AC/GG) Genotype in Saudi Kidney Transplant Recipients.” | 0.90 | hgvs_regex_v1 |