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2 records shown · first 60CYP2D6 genetic polymorphisms in Saudi systemic lupus erythematosus patients: A cross-sectional study.
PMID 36940959 | PMCID PMC10043891 | DOI 10.15537/smj.2023.44.3.20220581 · Saudi medical journal · 2023 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1080985 | “OBJECTIVES: To determine the prevalence of selected single nucleotide polymorphisms (rs1080985, rs28624811, rs1065852, rs28371725, and rs1135840) in cytochrome P450 2D6 (CYP2D6) gene among Saudi systemic lupus erythematosus (SLE) patients and to investigate the association between the genetic variants and clinical features of SLE.” | 0.90 | hgvs_regex_v1 |
| gene | CYP2D6 | “CYP2D6 genetic polymorphisms in Saudi systemic lupus erythematosus patients: A cross-sectional study.” | 0.98 | hgnc_dict_v1 |
| phenotype | systemic lupus erythematosus | “CYP2D6 genetic polymorphisms in Saudi systemic lupus erythematosus patients: A cross-sectional study.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia, Riyadh | “CYP2D6 genetic polymorphisms in Saudi systemic lupus erythematosus patients: A cross-sectional study. OBJECTIVES: To determine the prevalence of selected single nucleotide polymorphisms (rs1080985, rs28624811, rs1065852, rs28371725, and rs1135840) in cytochrome P450 2D6 (CYP2D6) gene among Saudi systemic lupus erythematosus (SLE) patients and to investigate the association between the genetic variants and clinical features of SLE. METHODS: This cross-sectional study was carried out on adult Saudi patients at King Khalid University Hospital, Riyadh, Saudi Arabia. RESULTS: There were 107 participants included in this study.” | 0.95 | saudi_context_rules_v1 |
Bisoprolol responses (PK/PD) in hypertensive patients: A cytochrome P450 (CYP) 2D6 targeted polymorphism study.
PMID 32994732 | PMCID PMC7499297 | DOI 10.1016/j.sjbs.2020.06.022 · Saudi journal of biological sciences · 2020 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1080985 | “This study aimed at investigating the association of CYP2D6*2A (rs1080985) and CYP2D6*10 (rs1065852) single-nucleotide polymorphism (SNP) with Bisoprolol response in cardiac patients attending King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia.” | 0.90 | hgvs_regex_v1 |
| gene | CYP2D6 | “This study aimed at investigating the association of CYP2D6*2A (rs1080985) and CYP2D6*10 (rs1065852) single-nucleotide polymorphism (SNP) with Bisoprolol response in cardiac patients attending King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | MAF | “CYP2D6*2A allele was detected in the homozygous wild type (GG) in 70 out of 107 patients, the heterozygous (GC) in 19 patients, and the homozygous mutant (CC) in 18 patients with minor allele frequency (MAF) of 25.7%.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia, Jeddah | “This study aimed at investigating the association of CYP2D6*2A (rs1080985) and CYP2D6*10 (rs1065852) single-nucleotide polymorphism (SNP) with Bisoprolol response in cardiac patients attending King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia. PATIENTS AND METHODS: In the study, 107 patients were enrolled.” | 0.95 | saudi_context_rules_v1 |