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4 records shown · first 60Prospective Functions of miRNA Variants May Predict Breast Cancer Among Saudi Females.
PMID 37899898 | PMCID PMC10611986 | DOI 10.7759/cureus.47849 · Cureus · 2023 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs11614913 | “Methods One hundred fifty-four females, including 76 females diagnosed with BC and 78 healthy controls, were analyzed using TaqMan™ (Thermo Fischer Scientific, Waltham, MA) genotyping assays for the miR-196a2 rs11614913 C>T, miR-146a rs2910164 C>G, and miR-499 rs3746444 A>G.” | 0.90 | hgvs_regex_v1 |
| phenotype | breast cancer | “Prospective Functions of miRNA Variants May Predict Breast Cancer Among Saudi Females.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Prospective Functions of miRNA Variants May Predict Breast Cancer Among Saudi Females. BC is a significant public health in females worldwide, where it remains the leading cause of death among Saudi females. Here, we evaluate the susceptibility of the miRNA genetic variants to the risk of BC in Saudi females. Methods One hundred fifty-four females, including 76 females diagnosed with BC and 78 healthy controls, were analyzed using TaqMan™ (Thermo Fischer Scientific, Waltham, MA) genotyping assays for the miR-196a2 rs11614913 C>T, miR-146a rs2910164 C>G, and miR-499 rs3746444 A>G.” | 0.95 | saudi_context_rules_v1 |
| variant | rs2910164 | “Methods One hundred fifty-four females, including 76 females diagnosed with BC and 78 healthy controls, were analyzed using TaqMan™ (Thermo Fischer Scientific, Waltham, MA) genotyping assays for the miR-196a2 rs11614913 C>T, miR-146a rs2910164 C>G, and miR-499 rs3746444 A>G.” | 0.90 | hgvs_regex_v1 |
Differential impact of the angiotensin-converting enzyme-2 (ACE2 rs4343 G>A) and miR-196a2 rs11614913 C>T gene alterations in COVID-19 disease severity and mortality.
PMID 35601073 | PMCID PMC9117950 | DOI 10.3892/etm.2022.11345 · Experimental and therapeutic medicine · 2022 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs11614913 | “Differential impact of the angiotensin-converting enzyme-2 (ACE2 rs4343 G>A) and miR-196a2 rs11614913 C>T gene alterations in COVID-19 disease severity and mortality.” | 0.90 | hgvs_regex_v1 |
| gene | ACE2 | “Differential impact of the angiotensin-converting enzyme-2 (ACE2 rs4343 G>A) and miR-196a2 rs11614913 C>T gene alterations in COVID-19 disease severity and mortality.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “Differential impact of the angiotensin-converting enzyme-2 (ACE2 rs4343 G>A) and miR-196a2 rs11614913 C>T gene alterations in COVID-19 disease severity and mortality.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | coronary artery disease | “A strong correlation between the ACE2 rs4343 G>A genotype distribution among COVID-19 patients was reported with respect to their comorbid conditions including sex (P<0.023), coronary artery disease (P<0.0001), oxygen saturation <60 mm Hg (P<0.0009) and antiviral therapy (0.003).” | 0.98 | phenotype_alias_lexicon_v2 |
Potential impact of GCK, MIR-196A-2 and MIR-423 gene abnormalities on the development and progression of type 2 diabetes mellitus in Asir and Tabuk regions of Saudi Arabia.
PMID 35293603 | PMCID PMC8941532 | DOI 10.3892/mmr.2022.12675 · Molecular medicine reports · 2022 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs11614913 | “Likewise, the CT genotype and T allele of MIR‑196A‑2 rs11614913 were associated with an increased risk of T2DM (OR=2.36, P=0.0059 and OR=1.74, P=0.023, respectively).” | 0.90 | hgvs_regex_v1 |
| gene | GCK | “Potential impact of GCK, MIR-196A-2 and MIR-423 gene abnormalities on the development and progression of type 2 diabetes mellitus in Asir and Tabuk regions of Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Potential impact of GCK, MIR-196A-2 and MIR-423 gene abnormalities on the development and progression of type 2 diabetes mellitus in Asir and Tabuk regions of Saudi Arabia.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia, Asir | “Potential impact of GCK, MIR-196A-2 and MIR-423 gene abnormalities on the development and progression of type 2 diabetes mellitus in Asir and Tabuk regions of Saudi Arabia. In the present study, the association of the single nucleotide polymorphisms (SNPs) in the GCK, MIR‑196A‑2 and MIR‑423 genes with susceptibility to T2DM in patients from two regions of Saudi Arabia were examined, using the tetra‑primer amplification refractory mutation system.” | 0.95 | saudi_context_rules_v1 |
Association of single nucleotide polymorphisms in microRNAs with susceptibility to hepatitis B virus infection and HBV-related liver complications: A study in a Saudi Arabian population.
PMID 28685993 | DOI 10.1111/jvh.12749 · Journal of viral hepatitis · 2017 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs11614913 | “In addition, we found that rs2292832 and rs11614913 were associated with risk of HBV infection, viral clearance and cirrhosis+HCC, whereas rs2910164 was associated with proneness to HBV infection, and ability to clear the virus.” | 0.90 | hgvs_regex_v1 |
| phenotype | hepatitis B | “Association of single nucleotide polymorphisms in microRNAs with susceptibility to hepatitis B virus infection and HBV-related liver complications: A study in a Saudi Arabian population.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | hepatocellular carcinoma | “The aim of this study was to evaluate the association of 10 SNPs in different microRNAs (miRNAs) with susceptibility to hepatitis B virus (HBV) infection, HBV clearance, persistence of chronic HBV infection, and progression to liver cirrhosis and hepatocellular carcinoma (HCC).” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Association of single nucleotide polymorphisms in microRNAs with susceptibility to hepatitis B virus infection and HBV-related liver complications: A study in a Saudi Arabian population. SNPs in miRNAs affect the susceptibility, clearance and progression of HBV infection in Saudi Arabian patients.” | 0.95 | saudi_context_rules_v1 |