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2 records shown · first 60TGF-β1 Gene Polymorphisms in Saudi Patients With Type 2 Diabetes With or Without Diabetic Nephropathy.
PMID 41928773 | PMCID PMC13042335 | DOI 10.1155/ije/6498033 · International journal of endocrinology · 2026 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800469 | “This study aimed to determine the genotypic and allelic frequencies of the TGF-β1 gene (rs1800469 and rs1800470) as well as to test whether there is an association between TGF-β1 single-nucleotide polymorphisms (SNPs) and DN development in Saudi patients with T2D.” | 0.90 | hgvs_regex_v1 |
| phenotype | diabetes mellitus | “TGF-β1 Gene Polymorphisms in Saudi Patients With Type 2 Diabetes With or Without Diabetic Nephropathy.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “TGF-β1 Gene Polymorphisms in Saudi Patients With Type 2 Diabetes With or Without Diabetic Nephropathy. This study aimed to determine the genotypic and allelic frequencies of the TGF-β1 gene (rs1800469 and rs1800470) as well as to test whether there is an association between TGF-β1 single-nucleotide polymorphisms (SNPs) and DN development in Saudi patients with T2D. METHODS: This case-control study involved 204 samples, including 76 controls, 81 patients with T2D without DN, and 47 patients with T2D with DN. TGF-β1 rs1800469 and rs1800470 were not significantly associated with T2D development and DN progression in Saudi patients with diabetes.” | 0.95 | saudi_context_rules_v1 |
| variant | rs1800470 | “This study aimed to determine the genotypic and allelic frequencies of the TGF-β1 gene (rs1800469 and rs1800470) as well as to test whether there is an association between TGF-β1 single-nucleotide polymorphisms (SNPs) and DN development in Saudi patients with T2D.” | 0.90 | hgvs_regex_v1 |
A preliminary study of cytokine gene polymorphism effects on Saudi patients with colorectal cancer.
PMID 33294886 | PMCID PMC7841582 | DOI 10.15537/smj.2020.12.25543 · Saudi medical journal · 2020 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800469 | “OBJECTIVE: To determine the possible associations of polymorphisms in interleukin (IL)-8 (rs4073 T/A), IL-10 (rs1800896 A/G), IL-22 (rs1179251 C/G and rs2227485 C/T), IL-27 (rs17855750 T/G), and transforming growth factor beta 1 (TGFß1) (rs1800469 C/T) with colorectal cancer (CRC) susceptibility in Saudi patients.” | 0.90 | hgvs_regex_v1 |
| phenotype | colorectal cancer | “A preliminary study of cytokine gene polymorphism effects on Saudi patients with colorectal cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia, Riyadh | “A preliminary study of cytokine gene polymorphism effects on Saudi patients with colorectal cancer. OBJECTIVE: To determine the possible associations of polymorphisms in interleukin (IL)-8 (rs4073 T/A), IL-10 (rs1800896 A/G), IL-22 (rs1179251 C/G and rs2227485 C/T), IL-27 (rs17855750 T/G), and transforming growth factor beta 1 (TGFß1) (rs1800469 C/T) with colorectal cancer (CRC) susceptibility in Saudi patients. METHODS: The case-control study was carried out between July 2019 and January 2020 in King Khaled University Hospital, Riyadh, Saudi Arabia. A total of 70 patients with CRC and 70 healthy controls were included in the study.” | 0.95 | saudi_context_rules_v1 |
| variant | rs4073 | “OBJECTIVE: To determine the possible associations of polymorphisms in interleukin (IL)-8 (rs4073 T/A), IL-10 (rs1800896 A/G), IL-22 (rs1179251 C/G and rs2227485 C/T), IL-27 (rs17855750 T/G), and transforming growth factor beta 1 (TGFß1) (rs1800469 C/T) with colorectal cancer (CRC) susceptibility in Saudi patients.” | 0.90 | hgvs_regex_v1 |