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2 records shown · first 60TGF-β1 Gene Polymorphisms in Saudi Patients With Type 2 Diabetes With or Without Diabetic Nephropathy.
PMID 41928773 | PMCID PMC13042335 | DOI 10.1155/ije/6498033 · International journal of endocrinology · 2026 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800470 | “This study aimed to determine the genotypic and allelic frequencies of the TGF-β1 gene (rs1800469 and rs1800470) as well as to test whether there is an association between TGF-β1 single-nucleotide polymorphisms (SNPs) and DN development in Saudi patients with T2D.” | 0.90 | hgvs_regex_v1 |
| phenotype | diabetes mellitus | “TGF-β1 Gene Polymorphisms in Saudi Patients With Type 2 Diabetes With or Without Diabetic Nephropathy.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “TGF-β1 Gene Polymorphisms in Saudi Patients With Type 2 Diabetes With or Without Diabetic Nephropathy. This study aimed to determine the genotypic and allelic frequencies of the TGF-β1 gene (rs1800469 and rs1800470) as well as to test whether there is an association between TGF-β1 single-nucleotide polymorphisms (SNPs) and DN development in Saudi patients with T2D. METHODS: This case-control study involved 204 samples, including 76 controls, 81 patients with T2D without DN, and 47 patients with T2D with DN. TGF-β1 rs1800469 and rs1800470 were not significantly associated with T2D development and DN progression in Saudi patients with diabetes.” | 0.95 | saudi_context_rules_v1 |
| variant | rs1800469 | “This study aimed to determine the genotypic and allelic frequencies of the TGF-β1 gene (rs1800469 and rs1800470) as well as to test whether there is an association between TGF-β1 single-nucleotide polymorphisms (SNPs) and DN development in Saudi patients with T2D.” | 0.90 | hgvs_regex_v1 |
Impacts of circulating cytokine levels and gene polymorphism predisposition on type 1 diabetes mellitus.
PMID 39231486 | PMCID PMC11374510 | DOI 10.6065/apem.2346178.089 · Annals of pediatric endocrinology & metabolism · 2024 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs1800470 | “RESULTS: The levels of 3 circulating cytokines (transforming growth factor [TGF]-β1, interleukin [IL]-10, and IL-6) and 6 SNPs in 3 cytokine genes (TGF-β1 [rs1800470 and rs1800471], IL-10 [rs1800896, rs1800871, and rs1800872], and IL-6 [rs1800795]) that contribute to genetic susceptibility were measured by enzyme-linked immunosorbent assay and polymerase chain reaction with sequence-specific primers.” | 0.90 | hgvs_regex_v1 |
| phenotype | diabetes mellitus | “Impacts of circulating cytokine levels and gene polymorphism predisposition on type 1 diabetes mellitus.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “The aim of this study was to investigate the roles of cytokine levels and the association of single-nucleotide polymorphisms (SNPs) within cytokine genes with T1DM in Saudi children. Moreover, our data demonstrated no appreciable diferences in circulating serum level or genotype and phenotype of IL- 10 between the patients and controls. CONCLUSION: This kind of measurement, which considers the prediction of T1DM, may be useful in assessing the severity of T1DM and susceptibility to T1DM among Saudi children.” | 0.95 | saudi_context_rules_v1 |
| variant | rs1800471 | “RESULTS: The levels of 3 circulating cytokines (transforming growth factor [TGF]-β1, interleukin [IL]-10, and IL-6) and 6 SNPs in 3 cytokine genes (TGF-β1 [rs1800470 and rs1800471], IL-10 [rs1800896, rs1800871, and rs1800872], and IL-6 [rs1800795]) that contribute to genetic susceptibility were measured by enzyme-linked immunosorbent assay and polymerase chain reaction with sequence-specific primers.” | 0.90 | hgvs_regex_v1 |