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1 records shown · first 60IFN-gamma and TNF associated with severe falciparum malaria infection in Saudi pregnant women.
PMID 25124540 | PMCID PMC4137072 | DOI 10.1186/1475-2875-13-314 · Malaria journal · 2014 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs2069705 | “BACKGROUND: Tumour necrosis factor (TNF) and interferon gamma (IFN-γ), encoded by TNF-836 C/A (rs 1800630) and IFN-γ -1616 C/T (rs2069705) genes, are key immunological mediators that are believed to both play protective and pathological roles in malaria.” | 0.90 | hgvs_regex_v1 |
| phenotype | malaria | “IFN-gamma and TNF associated with severe falciparum malaria infection in Saudi pregnant women.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia, Jazan | “IFN-gamma and TNF associated with severe falciparum malaria infection in Saudi pregnant women. METHODS: A prospective cohort (cross-sectional) study was conducted in pregnant women attending the out-patient clinic in King Fahad Specialist Hospital in Jazan (KFSHJ), with a clinical diagnosis of malaria. RESULTS: A hospital case-control study of severe malaria in a Saudi population identified strong associations with individual single-nucleotide polymorphisms in the TNF and IFN-γ genes, and defined TNF-836 C and IFN-γ-1616 T genotypes and alleles which were statistically significantly associated with severe malaria infection. CONCLUSIONS: This data provides a starting point for functional and genetic analysis of the TNF and IFN-γ genomic region in malaria infection affecting Saudi populations.” | 0.95 | saudi_context_rules_v1 |