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1 records shown · first 60New susceptibility locus for obesity and dyslipidaemia on chromosome 3q22.3.
PMID 23738802 | PMCID PMC3681549 | DOI 10.1186/1479-7364-7-15 · Human genomics · 2013 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs253662 | “Interestingly, rs253662 (p = 0.014) and rs6782181 (p = 0.019) were protective against acquiring high low-density lipoprotein-cholesterol (hLDL-chol) levels (p = 0.014), while rs1720819 showed similar effects against CAD (p < 0.0001).” | 0.90 | hgvs_regex_v1 |
| gene | MRAS | “BACKGROUND: The muscle Ras (MRAS) gene resides on chromosome 3q22.3 and encodes a member of the membrane-associated Ras small GTPase proteins, which function as signal transducers in multiple processes including cell growth and differentiation.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “New susceptibility locus for obesity and dyslipidaemia on chromosome 3q22.3.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | coronary artery disease | “In a preliminary study in heterozygous familial hypercholesterolaemia, we identified a locus linking the early onset of coronary artery disease (CAD) to chromosome 3q.22 and elected to sequence the MRAS gene using the MegaBACE DNA analysis system.” | 0.98 | phenotype_alias_lexicon_v2 |