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1 records shown · first 60Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.
PMID 35801810 | PMCID PMC9367647 | DOI 10.1080/07853890.2022.2096257 · Annals of medicine · 2022 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4667485 | “In addition, both rs4667485 and rs1469649 of SCN2A gene were significantly correlated to epilepsy risk for both allelic (4e-4 and 1e-3) and genotypic (1e-3 and 5e-3).” | 0.90 | hgvs_regex_v1 |
| gene | SCN1A | “RESULTS: Within SCN1A gene we found that the rs6432861 (p = 0.014) was in correlation with the risk of epilepsy.” | 0.98 | hgnc_dict_v1 |
| gene | SCN2A | “In addition, both rs4667485 and rs1469649 of SCN2A gene were significantly correlated to epilepsy risk for both allelic (4e-4 and 1e-3) and genotypic (1e-3 and 5e-3).” | 0.98 | hgnc_dict_v1 |
| gene | SCN3A | “Furthermore, these variant are essential for the disorder prognosis and medications outcomes.Key MessagesGenetic polymorphisms of sodium channels SCN1A, SCN2A and SCN3A were found to be associated with the risk of epilepsy.SCN1B polymorphisms were found to be correlated to epilepsy reduced risk.SCNs variants are involved in the epilepsy prognosis and response to treatment.” | 0.98 | hgnc_dict_v1 |