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2 records shown · first 60Association of Toll-Like Receptor 3 Single-Nucleotide Polymorphisms and Hepatitis C Virus Infection.
PMID 28127569 | PMCID PMC5239973 | DOI 10.1155/2017/1590653 · Journal of immunology research · 2017 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs5743314 | “The rs5743314 was also strongly associated with HCV-related liver disease progression (cirrhosis and HCC).” | 0.90 | hgvs_regex_v1 |
| gene | TLR3 | “Toll-like receptor 3 (TLR3) plays a key role in innate immunity by recognizing pathogenic, double-stranded RNAs.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatitis C | “Association of Toll-Like Receptor 3 Single-Nucleotide Polymorphisms and Hepatitis C Virus Infection.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | hepatocellular carcinoma | “Although downregulation of TLR3 gene expression has been mainly reported in patients infected with hepatitis C virus (HCV), the influence of TLR3 genotype on the risk of HCV infection, HCV-related cirrhosis, and/or hepatocellular carcinoma (HCC) remains to be determined.” | 0.98 | phenotype_alias_lexicon_v2 |
Toll-like receptor 3 polymorphism and its association with hepatitis B virus infection in Saudi Arabian patients.
PMID 22825813 | DOI 10.1002/jmv.23271 · Journal of medical virology · 2012 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs5743314 | “A total of 707 patients and 600 uninfected controls were examined for different parameters including the nine SNPs (rs5743311, rs5743312, rs1879026, rs5743313, rs5743314, rs5743315, rs111611328, rs78726532 and a newly identified SNP located at position 184322913 of chr4).” | 0.90 | hgvs_regex_v1 |
| gene | TLR3 | “TLR3 is part of the innate immune system that recognizes double-stranded RNA (dsRNA) and provides early immune response to exogenous antigens.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatitis B | “Toll-like receptor 3 polymorphism and its association with hepatitis B virus infection in Saudi Arabian patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | hepatocellular carcinoma | “Hepatitis B virus (HBV) is the major causative agent of chronic liver complications including cirrhosis and hepatocellular carcinoma (HCC).” | 0.98 | phenotype_alias_lexicon_v2 |