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5 records shown · first 60Interaction between the TCF7L2 gene and dietary intake on metabolic syndrome risk factors among Saudi Arabian adults.
PMID 40170676 | PMCID PMC11960299 | DOI 10.3389/fnut.2025.1513088 · Frontiers in nutrition · 2025 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs7903146 | “The single-nucleotide polymorphism (SNP) rs7903146 in TCF7L2 in T2D interacts with dietary factors; however, research on nutrigenetics among Saudi Arabians is limited.” | 0.90 | hgvs_regex_v1 |
| gene | TCF7L2 | “Interaction between the TCF7L2 gene and dietary intake on metabolic syndrome risk factors among Saudi Arabian adults.” | 0.98 | hgnc_dict_v1 |
| phenotype | metabolic syndrome | “Interaction between the TCF7L2 gene and dietary intake on metabolic syndrome risk factors among Saudi Arabian adults.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | obesity | “METHODS: This cross-sectional study included 271 adult participants (aged 20-55 years) of both genders with or without overweight or obesity (body mass index between 18-35 kg/m2).” | 0.98 | phenotype_alias_lexicon_v2 |
Saudi Community-Based Screening Study on Genetic Variants in β-Cell Dysfunction and Its Role in Women with Gestational Diabetes Mellitus.
PMID 37107681 | PMCID PMC10137495 | DOI 10.3390/genes14040924 · Genes · 2023 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs7903146 | “The purpose of this study was to investigate the genes associated with β-cell dysfunction and their genetic roles in the rs7903146, rs2237892, and rs5219 variants in Saudi women diagnosed with type 2 diabetes mellitus and GDM.” | 0.90 | hgvs_regex_v1 |
| gene | TCF7L2 | “TCF7L2, KCNQ1, and KCNJ11 genes are connected to the mechanism of β-cell dysfunction.” | 0.98 | hgnc_dict_v1 |
| gene | KCNQ1 | “TCF7L2, KCNQ1, and KCNJ11 genes are connected to the mechanism of β-cell dysfunction.” | 0.98 | hgnc_dict_v1 |
| gene | KCNJ11 | “TCF7L2, KCNQ1, and KCNJ11 genes are connected to the mechanism of β-cell dysfunction.” | 0.98 | hgnc_dict_v1 |
Type 2 diabetes mellitus susceptibility gene TCF7L2 is strongly associated with hyperglycemia in the Saudi Arabia Population of the eastern province of Saudi Arabia.
PMID 26367734 · European review for medical and pharmacological sciences · 2015 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs7903146 | “OBJECTIVE: We studied the association of single nucleotide polymorphisms (SNPs) rs7903146, rs12255372 and rs4506565 in type 2 diabetes mellitus (T2DM) susceptibility gene, transcription factor 7 like 2 (TCF7L2) with T2DM among the population of the Eastern Province of Saudi Arabia.” | 0.90 | hgvs_regex_v1 |
| gene | TCF7L2 | “Type 2 diabetes mellitus susceptibility gene TCF7L2 is strongly associated with hyperglycemia in the Saudi Arabia Population of the eastern province of Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Type 2 diabetes mellitus susceptibility gene TCF7L2 is strongly associated with hyperglycemia in the Saudi Arabia Population of the eastern province of Saudi Arabia.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia, Eastern Province | “Type 2 diabetes mellitus susceptibility gene TCF7L2 is strongly associated with hyperglycemia in the Saudi Arabia Population of the eastern province of Saudi Arabia. OBJECTIVE: We studied the association of single nucleotide polymorphisms (SNPs) rs7903146, rs12255372 and rs4506565 in type 2 diabetes mellitus (T2DM) susceptibility gene, transcription factor 7 like 2 (TCF7L2) with T2DM among the population of the Eastern Province of Saudi Arabia. PATIENTS AND METHODS: In a case-control study, blood samples were collected from 359 T2DM patients and 351 age and sex-matched normoglycemic controls. RESULTS: Our results revealed a strong association between risk T alleles in variants rs12255372 (OR: G/T=1.4233; T/T=2.0395) and rs4506565 (OR: A/T=1.6066; T/T=3.1301) and T2DM among the Saudi population of the Eastern Province of Saudi Arabia. This is the first time that this association has been identified in a Saudi population. These data further strengthens the hypothesis that Saudi populations might carry a distinct risk allele in T2DM susceptibility gene TCF7L2. CONCLUSIONS: The present results confirm that rs12255372 and rs4506565 variants of TCF7L2 show an association, but not rs7903146, with T2DM for the Saudi population of the Eastern Province of Saudi Arabia.” | 0.95 | saudi_context_rules_v1 |
Association between type 2 diabetes mellitus-related SNP variants and obesity traits in a Saudi population.
PMID 24435973 | DOI 10.1007/s11033-014-3022-z · Molecular biology reports · 2014 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs7903146 | “Variants of SNPs rs7903146, rs1552224 and rs11642841 in the control group and rs7903146 in T2DM group showed significant association with both BMI and WC.” | 0.90 | hgvs_regex_v1 |
| phenotype | obesity | “Association between type 2 diabetes mellitus-related SNP variants and obesity traits in a Saudi population.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | diabetes mellitus | “Association between type 2 diabetes mellitus-related SNP variants and obesity traits in a Saudi population.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Association between type 2 diabetes mellitus-related SNP variants and obesity traits in a Saudi population. In addition to the environmental factors, genetic factors may also contribute to the ongoing obesity epidemic in Saudi Arabia. This study investigated the association between variants of 36 previously established T2DM SNPs and obesity phenotypes in a population of Saudi subjects. Study subjects consisted of 975 obese (BMI: ≥30), 825 overweight (25-30) and 423 lean controls (18-25) and of these 927 had a history of T2DM.” | 0.95 | saudi_context_rules_v1 |
Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.
PMID 18655717 | PMCID PMC2515290 | DOI 10.1186/1471-2350-9-72 · BMC medical genetics · 2008 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs7903146 | “BACKGROUND: The rs7903146 and rs12255372 variants of TCF7L2 have been strongly associated with type 2 diabetes (T2D) risk in most populations studied to date.” | 0.90 | hgvs_regex_v1 |
| gene | TCF7L2 | “Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “METHODS: We performed a case-control association study using 522 Saudi T2D patients (WHO criteria), and 346 controls (age > 60; fasting plasma glucose < 7 mmol/L).” | 0.95 | saudi_context_rules_v1 |