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1 records shown · first 60Association between HLA variations and chronic hepatitis B virus infection in Saudi Arabian patients.
PMID 24465366 | PMCID PMC3898905 | DOI 10.1371/journal.pone.0080445 · PloS one · 2014 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs9277535 | “Three single nucleotide polymorphisms (SNPs) belonged to HLA-DQ region (rs2856718, rs7453920 and rs9275572) and two SNPs belonged to HLA-DP (rs3077 and rs9277535) were studied.” | 0.90 | hgvs_regex_v1 |
| phenotype | hepatitis B | “Association between HLA variations and chronic hepatitis B virus infection in Saudi Arabian patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | hepatocellular carcinoma | “Hepatitis B virus (HBV) infection is a leading cause of liver diseases including cirrhosis and hepatocellular carcinoma.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Association between HLA variations and chronic hepatitis B virus infection in Saudi Arabian patients. The aim of this study was to investigate the role of HLA genetic polymorphisms and their possible role in HBV infection in Saudi Arabian patients. Variations in HLA genes were screened in 1672 subjects who were divided according to their clinical status into six categories as follows; clearance group, inactive carriers, active carriers, cirrhosis, hepatocellular carcinoma (HCC) patients and uninfected healthy controls. In conclusion, these results suggest that variations in HLA genes could affect susceptibility to and clearance of HBV infection in Saudi Arabian patients.” | 0.95 | saudi_context_rules_v1 |