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GAPDH and diabetes mellitus are reported together in 4 articles.
Gene
GAPDH
- HGNC
- HGNC:4141
34articles
34mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
4 records shown · first 60Metformin-mediated modulation of epigenetic regulators in type 2 diabetes: A study on differential expression of DNMT1, TET1, OGG1, and AID genes.
PMID 41087712 | DOI 10.1007/s00210-025-04700-z · Naunyn-Schmiedeberg's archives of pharmacology · 2026 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GAPDH | “Insulin resistance was induced in HepG2 cells, which were then treated with metformin and sulfonylureas at various concentrations and time intervals. qPCR was performed to study the differential expression of DNMT1, TET1, OGG1, and AID genes, using GAPDH as an internal control.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Metformin-mediated modulation of epigenetic regulators in type 2 diabetes: A study on differential expression of DNMT1, TET1, OGG1, and AID genes.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | DNMT1 | “Metformin-mediated modulation of epigenetic regulators in type 2 diabetes: A study on differential expression of DNMT1, TET1, OGG1, and AID genes.” | 0.98 | hgnc_dict_v1 |
| gene | TET1 | “Metformin-mediated modulation of epigenetic regulators in type 2 diabetes: A study on differential expression of DNMT1, TET1, OGG1, and AID genes.” | 0.98 | hgnc_dict_v1 |
Molecular pathways of oxidative stress in diabetes: redox imbalance and insulin pathway dysregulation.
PMID 41460371 | DOI 10.1007/s11033-025-11389-z · Molecular biology reports · 2025 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GAPDH | “A critical event in this process is the inhibition of GAPDH mediated by PARP-1, leading to the accumulation of glyceraldehyde-3-phosphate, which subsequently promotes the formation of AGE through methylglyoxal, augments PKC signalling, and enhances flux through the polyol and hexosamine pathways.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Molecular pathways of oxidative stress in diabetes: redox imbalance and insulin pathway dysregulation.” | 0.93 | phenotype_alias_lexicon_v2 |
Defining the Role of Isoeugenol from Ocimum tenuiflorum against Diabetes Mellitus-Linked Alzheimer's Disease through Network Pharmacology and Computational Methods.
PMID 35458596 | PMCID PMC9025232 | DOI 10.3390/molecules27082398 · Molecules (Basel, Switzerland) · 2022 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GAPDH | “Among these 14 genes, GAPDH and AKT1 were the most significant.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Defining the Role of Isoeugenol from Ocimum tenuiflorum against Diabetes Mellitus-Linked Alzheimer's Disease through Network Pharmacology and Computational Methods.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | AKT1 | “Among these 14 genes, GAPDH and AKT1 were the most significant.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Defining the Role of Isoeugenol from Ocimum tenuiflorum against Diabetes Mellitus-Linked Alzheimer's Disease through Network Pharmacology and Computational Methods.” | 0.93 | phenotype_alias_lexicon_v2 |
Reference genes for expression studies in hypoxia and hyperglycemia models in human umbilical vein endothelial cells.
PMID 25193495 | PMCID PMC4232541 | DOI 10.1534/g3.114.013102 · G3 (Bethesda, Md.) · 2014 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GAPDH | “These were ribosomal protein large P0 (RPLP0), transferrin receptor (TFRC), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), β-glucuronidase (GUSB), and β-actin (ACTB).” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Human umbilical vein endothelial cell (HUVEC)-based gene expression studies performed under hypoxia and/or hyperglycemia show huge potential for modeling endothelial cell response in cardiovascular disease and diabetes.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | RPLP0 | “These were ribosomal protein large P0 (RPLP0), transferrin receptor (TFRC), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), β-glucuronidase (GUSB), and β-actin (ACTB).” | 0.98 | hgnc_dict_v1 |
| gene | TFRC | “These were ribosomal protein large P0 (RPLP0), transferrin receptor (TFRC), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), β-glucuronidase (GUSB), and β-actin (ACTB).” | 0.98 | hgnc_dict_v1 |