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POLE and endometrial cancer are reported together in 4 articles.
Gene
POLE
- HGNC
- HGNC:9177
11articles
11mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Endometrial cancer
49articles
49mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
4 records shown · first 60Molecular Classification of Endometrial Carcinoma: Insights From a Teaching Hospital.
PMID 39982210 | DOI 10.1097/PGP.0000000000001096 · International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | POLE | “We identified 100 cases of endometrial carcinoma, which were eventually classified using immunostains for mismatch repair (MMR) and p53 proteins, in addition to Sanger analysis for POLE gene (Ex, 9, 13, 14).” | 0.98 | hgnc_dict_v1 |
| phenotype | endometrial cancer | “Molecular Classification of Endometrial Carcinoma: Insights From a Teaching Hospital.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “We identified 100 cases of endometrial carcinoma, which were eventually classified using immunostains for mismatch repair (MMR) and p53 proteins, in addition to Sanger analysis for POLE gene (Ex, 9, 13, 14). This is the first study conducted in Saudi Arabia that investigated the prevalence and implications of these molecular subtypes in endometrial carcinoma.” | 0.95 | saudi_context_rules_v1 |
Prognostic Role of L1CAM in Endometrial Cancer.
PMID 40870967 | PMCID PMC12385864 | DOI 10.3390/diagnostics15162115 · Diagnostics (Basel, Switzerland) · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | POLE | “It seems to be an important factor, especially in the non-specific molecular profile subgroup (p53 normal expression, MMR proficient, POLE not mutated) of endometrial cancer, and a factor predictive of the response to chemotherapy.” | 0.98 | hgnc_dict_v1 |
| phenotype | endometrial cancer | “Prognostic Role of L1CAM in Endometrial Cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | L1CAM | “Prognostic Role of L1CAM in Endometrial Cancer.” | 0.98 | hgnc_dict_v1 |
Correlation of PD-L1 immunohistochemical expression with microsatellite instability and p53 status in endometrial carcinoma.
PMID 36440057 | PMCID PMC9682341 | DOI 10.1016/j.eurox.2022.100172 · European journal of obstetrics & gynecology and reproductive biology: X · 2022 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | POLE | “The Cancer Genome Atlas molecular grouping of a given case of EC could be assessed by POLE gene mutation, mismatch repair (MMR) 'to reflect microsatellite instability' and p53 status, which has proved to be of prognostic value.” | 0.98 | hgnc_dict_v1 |
| phenotype | endometrial cancer | “Correlation of PD-L1 immunohistochemical expression with microsatellite instability and p53 status in endometrial carcinoma.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | MLH1 | “Immunohistochemical staining was applied using antibodies against PD-L1, MLH1, MSH2 and p53.” | 0.98 | hgnc_dict_v1 |
| gene | MSH2 | “Immunohistochemical staining was applied using antibodies against PD-L1, MLH1, MSH2 and p53.” | 0.98 | hgnc_dict_v1 |
Germline POLE and POLD1 proofreading domain mutations in endometrial carcinoma from Middle Eastern region.
PMID 31866764 | PMCID PMC6907229 | DOI 10.1186/s12935-019-1058-9 · Cancer cell international · 2019 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | POLE | “Germline POLE and POLD1 proofreading domain mutations in endometrial carcinoma from Middle Eastern region.” | 0.98 | hgnc_dict_v1 |
| phenotype | endometrial cancer | “Germline POLE and POLD1 proofreading domain mutations in endometrial carcinoma from Middle Eastern region.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | POLD1 | “Germline POLE and POLD1 proofreading domain mutations in endometrial carcinoma from Middle Eastern region.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia | “BACKGROUND: Endometrial carcinoma (EC) accounts for 5.8% of all cancers in Saudi females. METHODS: We performed Capture sequencing and Sanger sequencing to screen for proofreading domains of POLE and POLD1 genes in 432 EC cases, followed by evaluation of protein expression using immunohistochemistry.” | 0.95 | saudi_context_rules_v1 |