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2 records shown · first 60Significant Association Between Genetic Polymorphism of Insulin-Like Growth Factor-2 mRNA Binding Protein-2 and Type 2 Diabetes Mellitus: A Population-Based Case-Control Study.
PMID 39749895 | PMCID PMC11821720 | DOI 10.1002/jcla.25147 · Journal of clinical laboratory analysis · 2025 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4402960 | “The PCR-RFLP technique was used to determine the genotype of the IGF2BP2 gene for the SNPs rs4402960 (G>T) and rs1470579 (A>C).” | 0.90 | hgvs_regex_v1 |
| gene | IGF2BP2 | “OBJECTIVES: To determine the association between IGF2BP2 polymorphisms and type 2 diabetes mellitus.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Significant Association Between Genetic Polymorphism of Insulin-Like Growth Factor-2 mRNA Binding Protein-2 and Type 2 Diabetes Mellitus: A Population-Based Case-Control Study.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “METHODS: This study involved 422 individuals, 214 diabetes mellitus cases, and 208 healthy controls. CONCLUSION: The present study showed that IGF2BP2 rs1470579 and rs4402960 polymorphism were significantly associated with the increased risk of T2DM in the Saudi Arabian population and presented a genetic model to screen the high-risk individuals with further validations.” | 0.95 | saudi_context_rules_v1 |
Significant association between insulin-like growth factor 2 mRNA-binding protein 2, interleukin-6 polymorphisms, and type 2 diabetes mellitus.
PMID 39764221 | PMCID PMC11702346 | DOI 10.4103/jrms.jrms_717_23 · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4402960 | “The polymerase chain reaction restriction fragment length polymorphism was used to identify the genotype of the IGF2BP2 gene for the small nucleoproteins rs4402960 (G>T) and small nucleoproteins rs800795 (G>C).” | 0.90 | hgvs_regex_v1 |
| gene | IGF2BP2 | “BACKGROUND: The study aimed to detect the association between insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and interleukin-6 (IL-6) polymorphisms among type 2 diabetes mellitus (T2DM).” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Significant association between insulin-like growth factor 2 mRNA-binding protein 2, interleukin-6 polymorphisms, and type 2 diabetes mellitus.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “MATERIALS AND METHODS: This study involved 500 individuals; 250 obese DM cases and 250 healthy controls. CONCLUSION: The current study indicated that IGF2BP2 rs4402960 and IL-6 rs1800795 polymorphism were highly significantly associated with the increased risk of obese T2DM among the Saudi Arabian population and presented a genetic model to screen the high-risk individuals with further validations.” | 0.95 | saudi_context_rules_v1 |